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Our Products Are Cited in Thousands of Peer-Reviewed Publications. Explore the collection of citations for selected Adooq products
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KRAS G12C covalent inhibitor
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AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
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MDM2 degrader
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MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
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COX-2 抑制剂
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Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses.
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NAD+ Modulator
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KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.
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MPI inhibitor
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MLS0315771 is a potent competitive phosphomannose isomerase (MPI) inhibitor.
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Calpain inhibitor
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SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly.
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NGF inhibitor
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Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).
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TRPC6 inhibitor
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SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.
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Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.
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SIRT6 allosteric activator
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MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.
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