“alpha ergocryptine”的搜索结果

产品 1 到 50 共 642个

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  1. 5α-Pregnane-3β,6α-diol-20-one

    Catalog No. A20118
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    5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. 了解更多
  2. PROTAC ERα Degrader-2

    Catalog No. A19697
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    ERα degrader
    PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. 了解更多
  3. HIF-2α-IN-1

    Catalog No. A20631
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    HIF-2α inhibitor
    HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. IC50 value: ?? 500 nM Target: HIF-2α. 了解更多
  4. PROTAC ERRα ligand 2

    Catalog No. A18939
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    ERRα inverse agonist
    PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多
  5. Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH

    Catalog No. A19684
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    Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH is a drug for cancer. 了解更多
  6. PDGFRα kinase inhibitor 1

    Catalog No. A19632
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    type II PDGFRα kinase inhibitor
    PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively. 了解更多
  7. IFN alpha-IFNAR-IN-1 hydrochloride

    Catalog No. A21667
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    IFN-α and IFNAR interaction inhibitor
    IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). 了解更多
  8. PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  9. SJFα

    Catalog No. A18602
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    13-atom linker PROTAC
    SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M. 了解更多
  10. SNG-1153

    Catalog No. A22222
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    modulator of estrogen receptor ER-alpha36
    SNG-1153 is a modulator of estrogen receptor ER-alpha36. 了解更多
  11. Flutonidine

    Catalog No. A22620
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    alpha2-Adrenergic receptor agonist
    Flutonidine is an alpha2-Adrenergic receptor agonist. 了解更多
  12. STING agonist-1

    Catalog No. A12497
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    human-specific STING agonist
    STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. 了解更多
  13. Lexacalcitol

    Catalog No. A11482
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    Lexacalcitol (KH1060) is over 100 times more active than 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3], as judged by in vitro antiproliferative and cell differentiating assays. 了解更多
  14. PT2977

    Catalog No. A18465
    HIF-2alpha inhibitor
    PT2977 is HIF-2alpha inhibitor with an IC50 of 9 nM. 了解更多
  15. BIO-1211

    Catalog No. A17210
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    Integrin alpha4beta1 抑制剂
    BIO-1211是整联蛋白alpha4beta1抑制剂。 了解更多
  16. (R)-Equol

    Catalog No. A16986
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    Estrogen receptor 激动剂
    (R)-Equol是ER&alpha和ER&beta的激动剂,Kis分别为27.4和15.4 nM。 了解更多
  17. CWHM12

    Catalog No. A15967
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    αV integrins 抑制剂
    CWHM 12可以抑制所有5个alpha V整联蛋白。CWHM12不仅以与遗传删除方法相同的方式预防纤维化,还可以防止肝和肺中现有纤维化的进展,并逆转了由纤维化对这些器官造成的某些损害。 了解更多
  18. Oltipraz

    Catalog No. A13164
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    Nrf2 activator
    Oltipraz抑制HIF-1alpha活性和HIF-1alpha依赖性肿瘤生长,这可能是由于S6K1抑制结合H2O2清除作用导致HIF-1alpha稳定性降低所致。 了解更多
  19. PRT 4165

    Catalog No. A15453
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    Bmi1/Ring1A 抑制剂
    PRT 4165是Bmi1/Ring1A抑制剂,Bmi1/Ring1A是多梳抑制复合物1(PRC1)的亚基。它可以防止Bmi1/Ring1A介导的泛素化和拓扑异构酶2alpha的药物诱导降解。 了解更多
  20. K-7174 2HCl

    Catalog No. A15446
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    Cell adhesion 抑制剂
    K-7174 dihydrochloride是一种新型的细胞粘附抑制剂;抑制由IL-1beta或TNF-alpha诱导的血管细胞粘附分子1(VCAM-1)的表达。 了解更多
  21. K-7174

    Catalog No. A15445
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    Cell adhesion 抑制剂
    K-7174是一种新型的细胞粘附抑制剂;抑制由IL-1beta或TNF-alpha诱导的血管细胞粘附分子1(VCAM-1)的表达。 了解更多
  22. PI-103 Hydrochloride

    Catalog No. A15212
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    PI3K 抑制剂
    PI-103 Hydrochloride是对重组PI3K亚型p110alpha(IC50 = 2 nM),p110beta(IC50 = 3 nM),p110delta(IC50 = 3 nM)和p110gamma(IC50 = 15 nM)具有低IC50值的有效抑制剂,对mTOR的效力较低/DNA-PK,IC50为30 nM/23 nM。 了解更多
  23. 1alpha, 25-Dihydroxy VD2-D6

    Catalog No. A14969
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    1alpha, 25-Dihydroxy VD2-D6是氘化的维生素D形式。 了解更多
  24. 1alpha, 24, 25-Trihydroxy VD2

    Catalog No. A14968
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    1alpha, 24, 25-Trihydroxy VD2是维生素D类似物。 了解更多
  25. BNS-22

    Catalog No. A13443
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    Topo II 抑制剂
    BNS-22是Topo II的有效小分子抑制剂(Topo II alpha和Topo II beta的IC50分别为2.8 M和0.42 M)。 了解更多
  26. Dexmedetomidine HCl

    Catalog No. A11846
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    alpha2-adrenoceptor 激动剂
    Dexmedetomidine hydrochloride是美托咪啶的活性异构体,它充当有效的,高度选择性的α2-AR(α2-肾上腺素受体)激动剂。 了解更多
  27. PX-478 HCl

    Catalog No. A14319
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    HIF-1alpha 抑制剂
    PX-478 HCl是HIF-1alpha抑制剂,也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性,可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子,具有良好的i.v.,i.p.和p.o.抗肿瘤活性。 了解更多
  28. Labetalol HCl

    Catalog No. A14239
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    alpha1/beta adrenergic receptors 拮抗剂
    Labetalol HCl是选择性α1-肾上腺素能受体和非选择性β-肾上腺素能受体的双重拮抗剂。 了解更多
  29. Firategrast (SB 683699)

    Catalog No. A12787
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    α4β1/α4β7 integrin 拮抗剂
    Firategrast (SB 683699)是一种口服可生物利用的alpha4 beta1/alpha4 beta7整联蛋白拮抗剂,旨在减少淋巴细胞向中枢神经系统(CNS)的运输。 了解更多
  30. Crisaborole (AN2728)

    Catalog No. A12776
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    PDE4 抑制剂?
    AN2728是一种局部给药的含硼抗炎化合物,可抑制PDE4活性,从而抑制TNFalpha,IL-12,IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。 了解更多
  31. Lidocaine (Alphacaine)

    Catalog No. A10530
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    Lidocaine (Alphacaine)是一种麻醉剂和Ib类抗心律失常药。在失活状态下阻断电压门控钠通道。 了解更多
  32. Rosiglitazone (BRL-49653)

    Catalog No. A10807
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    PPAR 激动剂
    Rosiglitazone (BRL-49653)是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,在大鼠,3T3-L1和人体脂肪细胞中IC50分别为12,4和9 nM。Rosiglitazone是PPAR-gamma的配体,对PPAR-alpha没有结合力。 了解更多
  33. Dutasteride (Avodart)

    Catalog No. A10338
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    dual 5alpha-reductase 抑制剂
    Dutasteride (Avodart)是双重的5-a还原酶抑制剂,可抑制睾丸激素转化为二氢睾丸激素(DHT)。 了解更多
  34. A66

    Catalog No. A11202
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    PI3K 抑制剂
    A66的S对映异构体是PI 3-激酶(PIK3CA)的p110alpha亚型的有效抑制剂。无细胞试验中IC50为32 nM,作用于p110α比作用于其他I类PI3K亚型选择性高100多倍。 了解更多
  35. Acarbose

    Catalog No. A10029
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    Anti-Diabetic Agent
    Acarbose是一种肠道alpha-glucosidase抑制剂,用于治疗2型糖尿病以及某些国家的前驱糖尿病。 了解更多
  36. α-2,3-sialyltransferase-IN-1

    Catalog No. A20249
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    α-2,3-sialyltransferase inhibitor
    α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM. 了解更多
  37. p38α inhibitor 1

    Catalog No. A19182
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    p38α inhibitor
    p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1. 了解更多
  38. α-Tocopherol phosphate

    Catalog No. A20866
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    α-Tocopherol phosphate is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from plant sources. 了解更多
  39. alpha-Amanitin

    Catalog No. A14097
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    alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II. 了解更多
  40. α-Lipoic Acid

    Catalog No. A17341
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    antioxidant
    α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. 了解更多
  41. TNF-α-IN-1

    Catalog No. A19687
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    TNF-α inhibitor
    TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7. 了解更多
  42. p38-α MAPK-IN-1

    Catalog No. A21036
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    MAPK14 inhibitor
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. 了解更多
  43. α-Hydroxytamoxifen

    Catalog No. A13540
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    α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts. 了解更多
  44. alpha-Bisabolol

    Catalog No. A18691
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    alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells. 了解更多
  45. α-Terpineol

    Catalog No. A17697
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    antifungal
    (L)-alpha-Terpineol is a monoterpene alcohol. It is one of the components responsible for the antifungal activity of Melaleuca alternifolia (tea tree) essential oil. α-Terpineol may be used in the synthesis of α-terpinyl esters of acetic acid and acetic anhydride via lipase-mediated esterification. 了解更多
  46. DL-alpha-Tocopherol

    Catalog No. A17816
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    antioxidation agent
    DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB. 了解更多
  47. RO 4938581

    Catalog No. A20022
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    GABAA α5 inverse agonist
    RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively). 了解更多
  48. (2R)-Octyl-α-hydroxyglutarate

    Catalog No. A19969
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    (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate. 了解更多
  49. Mirogabalin besylate

    Catalog No. A19379
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    ligand for the α2δ subunit of voltage-gated calcium channels
    Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. 了解更多
  50. (2S)-Octyl-α-hydroxyglutarate

    Catalog No. A21682
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    (2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate. 了解更多

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