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“gdc 0084”的搜索结果

46 个项目

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  1. GDC-0077
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    GDC-0077

    Catalog No. A19494
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    PI3Kα inhibitor
    GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). 了解更多
  2. GDC-0927 Racemate
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    GDC-0927 Racemate

    Catalog No. A21507
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    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. 了解更多
  3. GDC-0339
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    GDC-0339

    Catalog No. A20920
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    Pim kinase inhibitor
    GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. 了解更多
  4. GDC-0349
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    GDC-0349

    Catalog No. A11443
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    mTOR 抑制剂
    GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。 了解更多
  5. GDC-0326
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    GDC-0326

    Catalog No. A20437
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    PI3Kα inhibitor
    GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. 了解更多
  6. GDC-0927
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    GDC-0927

    Catalog No. A19747
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    estrogen receptor antagonist
    GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. 了解更多
  7. GDC-0575 dihydrochloride
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    GDC-0575 dihydrochloride

    Catalog No. A21567
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    CHK1 inhibitor
    GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多
  8. GDC-0575 (ARRY-575, RG7741)
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    GDC-0575 (ARRY-575, RG7741)

    Catalog No. A16811
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    Chk1 抑制剂
    GDC-0575 (ARRY-575,RG7741)是一种有效的选择性CHK1抑制剂，IC50为1.2 nM。 了解更多
  9. GDC-0152
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    GDC-0152

    Catalog No. A14135
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    IAP 拮抗剂
    GDC-0152是caspases（Smac）的第二个线粒体激活物，具有潜在的抗肿瘤活性。 了解更多
  10. GDC-0032 (Taselisib)
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    GDC-0032 (Taselisib)

    Catalog No. A12831
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    PI3K 抑制剂
    GDC-0032 (Taselisib)是有效的下一代PI3抑制剂，靶向PI3α。 了解更多
  11. GDC-0834 Racemate
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    GDC-0834 Racemate

    Catalog No. A12706
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    BTK 抑制剂
    GDC-0834 Racemate是一种有效且选择性的Bruton酪氨酸激酶（BTK）抑制剂，被研究用作类风湿关节炎的潜在治疗剂。 了解更多
  12. GDC-0879
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    GDC-0879

    Catalog No. A10420
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    B-Raf 抑制剂
    GDC-0879是B-Raf激酶的特异性抑制剂，靶向B-Raf (V600E) (IC50: 0.13 nM)。 了解更多
  13. GDC-0980 (Apitolisib, RG7422)
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    GDC-0980 (Apitolisib, RG7422)

    Catalog No. A11023
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    mTOR/PI3K 抑制剂
    GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。 了解更多
  14. GDC-0941 (Pictilisib)
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    GDC-0941 (Pictilisib)

    Catalog No. A10421
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    PI3K 抑制剂
    GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂，p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。 了解更多
  15. GDC-0834
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    GDC-0834

    Catalog No. A21243
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    BTK inhibitor
    GDC-0834 is a potent and selective BTK inhibitor. 了解更多
  16. GDC-0623
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    GDC-0623

    Catalog No. A12974
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    MEK1 抑制剂
    GDC-0623是一种有效的ATP竞争性MEK1抑制剂，Ki为0.13 nM。 了解更多
  17. GDC-0068 (Ipatasertib, RG-7440)
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    GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
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    Akt 抑制剂
    GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。 了解更多
  18. GDC-0449 (Vismodegib)
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    GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog 拮抗剂
    GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。 了解更多
  19. GDC-0810 (Brilanestrant)
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    GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    GDC-0810 (Brilanestrant)是一种口服可生物利用的选择性雌激素受体降解剂（SERD），在耐他莫昔芬的乳腺癌异种移植物中表现出强大的活性。 了解更多
  20. GDC-0973 (Cobimetinib)
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    GDC-0973 (Cobimetinib)

    Catalog No. A11441
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    MEK1 抑制剂
    GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂，IC50为4.2 nM，对MEK1的选择性选择性是对MEK2的100倍以上，并且当针对一组超过100个丝氨酸的抑制剂进行测试时，没有显示出明显的抑制作用。 了解更多
  21. C188-9
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    C188-9

    Catalog No. A16804
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    STAT3 抑制剂
    C188-9是一种有效的STAT3抑制剂，它以高亲和力（KD = 4.7±0.4 nM）与STAT3结合。C188-9在小鼠中具有良好的耐受性，显示出良好的口服生物利用度，并且集中在肿瘤中。 了解更多
  22. GF 109203X
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    GF 109203X

    Catalog No. A13197
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    PKC 抑制剂
    GF 109203X是一种有效且选择性的蛋白激酶C抑制剂，对α和β1亚型具有选择性（对于α，β1，δ，δ，ε和ζ亚型，IC50分别为0.0084、0.0180、0.210、0.132和5.8μM）。对MLCK，PKG和PKA具有选择性（IC50值分别为0.6、4.6和33μM）。5-HT3受体的强效拮抗剂（Ki = 29.5 nM）。= 29.5 nm)。 了解更多
  23. CHK1 inhibitor
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    CHK1 inhibitor

    Catalog No. A19623
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    CHK1 inhibitor
    CHK1 inhibitor (GDC-0575 analog) is an inhibitor of CHK1. 了解更多
  24. Pictilisib dimethanesulfonate
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    Pictilisib dimethanesulfonate

    Catalog No. A11444
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    PI3Kα/δ inhibitor
    Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). 了解更多
  25. GDC0994 (Ravoxertinib)
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    GDC0994 (Ravoxertinib)

    Catalog No. A13420
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    ERK1/2 抑制剂
    GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。 了解更多
  26. GDC046
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    GDC046

    Catalog No. A22299
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    TYK2 inhibitor
    GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor of TYK2 with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively. 了解更多
  27. Ipatasertib dihydrochloride
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    Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多
  28. CUDC-427
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    CUDC-427

    Catalog No. A20943
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    pan-selective IAP antagonist
    CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. 了解更多
  29. Cobimetinib hemifumarate
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    Cobimetinib hemifumarate

    Catalog No. A18033
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    MEK1 inhibitor
    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. 了解更多
  30. Belvarafenib
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    Belvarafenib

    Catalog No. A13177
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    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. 了解更多
  31. GDC0853
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    GDC0853

    Catalog No. A16339
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    BTK 抑制剂
    GDC0853是有效的口服BTK抑制剂。 了解更多
  32. Cobimetinib (racemate)
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    Cobimetinib (racemate)

    Catalog No. A15050
    MEK 抑制剂
    Cobimetinib (racemate)是一种有效的，高度选择性的MEK1/2抑制剂。 了解更多
  33. Cobimetinib (R-enantiomer)
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    Cobimetinib (R-enantiomer)

    Catalog No. A15051
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    MEK 抑制剂
    Cobimetinib R-enantiomer是Cobimetinib的R对映异构体，Cobimetinib是一种有力的，高选择性的促分裂原活化蛋白激酶（MEK1/2）抑制剂。 了解更多
  34. ABT-199 (Venetoclax)
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    ABT-199 (Venetoclax)

    Catalog No. A12500
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    Bcl-2 抑制剂
    ABT-199 (Venetoclax) 是一种所谓的BH3类似药物，旨在阻断Bcl 2蛋白的功能。 了解更多
  35. APX-115 free base
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    APX-115 free base

    Catalog No. A22055
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    pan NADPH oxidase (Nox) inhibitor
    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. 了解更多
  36. SB-224289 hydrochloride
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    SB-224289 hydrochloride

    Catalog No. A21920
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    5-HT1B receptor antagonist
    SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. 了解更多
  37. PF-06700841 P-Tosylate
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    PF-06700841 P-Tosylate

    Catalog No. A21652
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    dual JAK1/TYK2 inhibitor
    PF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. 了解更多
  38. MK-0429
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    MK-0429

    Catalog No. A21173
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    αvβ3 integrin antagonist
    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. 了解更多
  39. UAMC-3203
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    UAMC-3203

    Catalog No. A20084
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    Ferroptosis inhibitor
    UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. 了解更多
  40. PF-06700841 tosylate
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    PF-06700841 tosylate

    Catalog No. A17176
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    JAK1 and TYK2 抑制剂
    PF-06700841 tosylate是JAK1和TYK2激酶的抑制剂。 了解更多
  41. ECHS1 Human
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    ECHS1 Human

    Catalog No. AP4088
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    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial Human Recombinant 了解更多
  42. ECHS1 Human, Active
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    ECHS1 Human, Active

    Catalog No. AP4084
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    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial, Human Recombinant, Active 了解更多
  43. HSP90 Alpha Human
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    HSP90 Alpha Human

    Catalog No. AP0084
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    Heat Shock Protein-90 Alpha Human Recombinant 了解更多
  44. NVP-ACC789
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    NVP-ACC789

    Catalog No. A13240
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    VEGFR-2 抑制剂
    NVP-ACC789是VEGFR-2（FLK-1/KDR）的抑制剂。 了解更多
  45. G-479
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    G-479

    Catalog No. A14380
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    MEK 抑制剂
    G-479是有效的MEK抑制剂。在许多方面，极性分布在整个分子中的G-479被证明具有比GDC-0623更高的生物活性。 了解更多
  46. Arbutin (Uva, p-Arbutin)
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    Arbutin (Uva, p-Arbutin)

    Catalog No. A10084
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    Tyrosinase 抑制剂
    Arbutin (Uva,p-Arbutin)是用于中药（TCM）的糖基化对苯二酚。 熊果苷由于其酪氨酸酶抑制活性而抑制黑色素的形成。 了解更多

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  1. Epigenetics (3)
  2. Apoptosis (2)
  3. PI3K / Akt / mTOR (9)
  4. Protein Tyrosine Kinases (1)
  5. Angiogenesis (4)
  6. MAPK (9)
  7. JAK / Stat (4)
  8. Cell Cycle (2)
  9. Cytoskeleton (1)
  10. Cell Metabolism (1)
  11. GPCR / G Protein (1)
  12. TGF-β / Smad (1)
  13. Proteases (1)
  14. Stem Cells / Wnt (1)
  15. Endocrinology / Hormones (2)
  16. Natural Products (1)
  17. Ready to Use Solution (7)
  18. Products On Sale (13)
  19. Recombinant Proteins (1)
  20. Enzymes (2)
作用机制
  1. Inhibitor (抑制剂) (30)
  2. Antagonist (拮抗剂) (5)
  3. Degrader (降解剂) (2)
靶点
  1. AKT1 (1)
  2. AKT2 (1)
  3. AKT3 (1)
  4. B-Raf (1)
  5. Bcl-2 (1)
  6. Bcl-w (1)
  7. Bcl-xL (1)
  8. IAP (1)
  9. MEK1 (5)
  10. MEK2 (3)
  11. STAT3 (1)
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