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搜索结果：“gdc 0084”

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GDC-0152

Catalog No. A14135
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IAP 拮抗剂

GDC-0152是caspases（Smac）的第二个线粒体激活物，具有潜在的抗肿瘤活性。了解更多

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GDC-0449 (Vismodegib)

Catalog No. A10258
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Hedgehog 拮抗剂

GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。了解更多

Product Citations (3)

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- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
- Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
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CUDC-427

Catalog No. A20943
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pan-selective IAP antagonist

CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. 了解更多

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SB-224289 hydrochloride

Catalog No. A21920
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5-HT1B receptor antagonist

SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. 了解更多

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MK-0429

Catalog No. A21173
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αvβ3 integrin antagonist

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. 了解更多

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