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Cysteine protease

Cysteine protease

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Cysteine Protease	Other
A11265	Odanacatib (MK-0822)	****
A13257	E-64	***
A14245	PD 151746	*
A15295	Calpeptin	**
A11466	Cathepsin Inhibitor 1	***
A11901	PMSF		chymotrypsin
A13259	Aloxistatin
A13258	Loxistatin Acid (E-64C)
A14145	Leupeptin Hemisulfate		serine protease
A14284	Z-FA-FMK
A14220	MG-101 (ALLN)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SNJ-1945

Catalog No. A17243
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Calpain inhibitor

SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. 了解更多

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SID 26681509

Catalog No. A15313
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Human cathepsin L 抑制剂

SID 26681509是一种可逆的有效人组织蛋白酶L抑制剂。SID 26681509不显示组织蛋白酶G的抑制活性。了解更多

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L 006235

Catalog No. A15302
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Cathepsin K 抑制剂

L006235是一种有效的，可逆的组织蛋白酶K抑制剂（IC50 = 0.25 nM），其选择性超过组织蛋白酶B，L和S的4000倍。了解更多

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Z-FL-COCHO

Catalog No. A13502
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Cathepsin S 抑制剂

Z-FL-COCHO是新型的组织蛋白酶S抑制剂。了解更多

Product Citations (3)

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- Fu R, .et al. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjogren's syndrome murine model, Sci Rep, 2020, Jan 29;10(1):1455 PMID: 31996771
- Klinngam W, .et al. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sj?gren's Syndrome, Sci Rep, 2019, Jul 2;9(1):9559 PMID: 31267034
- Chen CY, .et al. Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation, Clin Sci (Lond), 2018, Oct 29;132(20):2221-2239 PMID: 30287519
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CA-074 Methyl Ester

Catalog No. A13593
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Cathepsin B 抑制剂

CA-074 Methyl Ester是CA-074的细胞渗透性类似物，用作不可逆组织蛋白酶B抑制剂。据报道，CA-074甲酯在啮齿动物模型中抑制骨吸收，并显示在体外抑制B16黑素瘤细胞侵袭。了解更多

Product Citations (4)

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- Qian Chu, .et al. Patulin induces pyroptosis through the autophagic-inflammasomal pathway in liver, Food Chem Toxicol, 2021, Jan;147:111867 PMID: 33217525
- Ye Tao, .et al. Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis, Chemosphere, 2020, Mar;242:124959 PMID: 31669990
- Ming Sun, .et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells, J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
- Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546
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E-64

Catalog No. A13257
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Cysteine Protease 抑制剂

E-64是一种不可逆的选择性半胱氨酸蛋白酶抑制剂，对木瓜蛋白酶的IC50为9 nM。了解更多

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Loxistatin Acid (E64-C)

Catalog No. A13258
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Cysteine Protease 抑制剂

Loxistatin Acid (E64-C)是E-64的衍生物，是不可逆的且可透过膜的半胱氨酸蛋白酶抑制剂。了解更多

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Odanacatib (MK-0822)

Catalog No. A11265
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Cathepsin K 抑制剂

Odanacatib (MK-0822)是组织蛋白酶K（一种参与骨吸收的酶）的抑制剂。了解更多

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Leupeptin hemisulfate

Catalog No. A14145
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Cysteine Protease 抑制剂

Leupeptin hemisulfate是胰蛋白酶样和半胱氨酸蛋白酶如钙蛋白酶的可逆抑制剂。了解更多

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E 64d (Aloxistatin)

Catalog No. A13259
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Cysteine Protease 抑制剂

E 64d (Aloxistatin)是组织蛋白酶B和L的抑制剂，具有溶酶体和细胞渗透性。了解更多

Product Citations (2)

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- Jason J McDougall, .et al. Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation, Mol Pain, 2021, 17 PMID: 34006144
- Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
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CA-074

Catalog No. A13256
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Cathepsin B 抑制剂

CA-074是组织蛋白酶B（cathepsin B）的有效抑制剂，Ki为2至5 nM。了解更多

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- Tianming Qiu, .et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway, Cell Death Dis, 2018, Oct; 9(10): 946 PMID: 30237538
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Cysteine Protease inhibitor

Catalog No. A21048
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cysteine protease inhibitor

Cysteine Protease inhibitor is an inhibitor of cysteine protease. 了解更多

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Z-FA-FMK

Catalog No. A16381
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Cysteine protease 抑制剂

Z-FA-FMK是半胱氨酸蛋白酶的不可逆抑制剂。了解更多

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Cathepsin Inhibitor 1

Catalog No. A11466
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Cathepsin 抑制剂

Cathepsin Inhibitor 1抑制剂1 是一种Cathepsin (L, L2, S, K, B)的抑制剂，pIC50分别为7.9、6.7、6.0、5.5和5.2。了解更多

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PD 150606

Catalog No. A15306
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Non-peptide calpain 抑制剂

PD 150606是针对钙蛋白酶1和针对钙蛋白酶2的钙蛋白酶抑制剂的一种细胞可渗透的，非竞争性，选择性，非肽的钙蛋白酶依赖性钙蛋白酶抑制剂，其针对钙蛋白酶的Ca2 +结合位点。了解更多

Product Citations (1)

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- Hisamatsu Y, .et al. Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex, Bioconjug Chem, 2017, Feb 15;28(2):507-523 PMID: 28032992
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MDL 28170

Catalog No. A15303
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Calpain 抑制剂 III

MDL 28170是钙蛋白酶1（Ca2+依赖的半胱氨酸蛋白酶）的细胞可渗透选择性抑制剂，已与免疫细胞和神经元细胞的凋亡有关。了解更多

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- Barker BS, .et al. Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus, Neuroscience, 2019, Nov 26. pii: S0306-4522(19)30796-1 PMID: 31783100
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Balicatib

Catalog No. A12020
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Cathepsin K 抑制剂

Balicatib是一种组织蛋白酶k抑制剂，刺激猴子骨膜骨形成。了解更多

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Calpeptin

Catalog No. A15295
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Calpain 抑制剂

Calpeptin是一种有效的、具有细胞穿透性的calpain抑制剂。了解更多

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Acetyl-Calpastatin (184-210) (human)

Catalog No. A15290
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Selective calpain 抑制剂

Acetyl-Calpastatin (184-210) (human)选择性钙蛋白酶抑制剂。强烈抑制钙蛋白酶I（Ki = 0.2 nM）和II，但不抑制木瓜蛋白酶，胰蛋白酶和组织蛋白酶L（Ki = 6 uM）。增加淀粉样β蛋白（Aβ）42，Aβ40和Aβ42比率的分泌。了解更多

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Calpain Inhibitor II, ALLM

Catalog No. A14911
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Calpain 抑制剂

Calpain Inhibitor II, ALLM是钙蛋白酶I，钙蛋白酶II，组织蛋白酶L和组织蛋白酶B的细胞可渗透抑制剂，Ki值分别为120 nM，230 nM，0.6 nM和100 nM。了解更多

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SJA6017

Catalog No. A13640
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reversible Calpain 抑制剂

SJA6017是一种细胞可渗透的肽醛，用作可逆钙蛋白酶抑制剂。了解更多

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MG-101

Catalog No. A14220
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Cysteine Protease 抑制剂

MG-101 (ALLN)是半胱氨酸蛋白酶（包括钙蛋白酶和溶酶体组织蛋白酶）的细胞渗透性强抑制剂。了解更多

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PD 151746

Catalog No. A14245
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Calpain 抑制剂

PD 151746是一种选择性的，细胞可渗透的钙蛋白酶抑制剂，对μ-钙蛋白酶的Ki值为0.26 uM，选择性是m-钙蛋白酶的20倍。了解更多

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Z-FA-FMK

Catalog No. A14284
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Irreversible Cysteine Protease 抑制剂

Z-FA-FMK是不可逆的半胱氨酸蛋白酶抑制剂。了解更多

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