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Product Data Sheet

ML-210

Catalog No. A20475

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ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue.
Adooq's ML-210 has been cited by 1 publications
  • Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
  • Chemical Information
    Catalog Num A20475
    M. Wt 475.32
    Formula C22H20Cl2N4O4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1360705-96-9
    Synonyms CID 49766530; CID-49766530; CID49766530; ML 210; ML210
    SMILES O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue.
    Solubility
    In vitro DMSO 14 mg/mL (29.45 mM)
    Water Insoluble
    Ethanol 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.04 mL 105.19 mL 210.38 mL
    0.5 mM 4.21 mL 21.04 mL 42.08 mL
    1 mM 2.1 mL 10.52 mL 21.04 mL
    5 mM 0.42 mL 2.1 mL 4.21 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
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