β-catenin

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Longdaysin

Catalog No. A21022
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Wnt/??-catenin signaling inhibitor

Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. 了解更多

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IWP-4

Catalog No. A17004
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Wnt/β-catenin signaling 抑制剂

IWP-4是Wnt /β-catenin信号传导的新型有效抑制剂。了解更多

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KYA1797K

Catalog No. A16353
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Wnt/beta-catenin 抑制剂

KYA1797K是一种高效且选择性的Wnt/β-catenin抑制剂，IC50为0.75 μM（TOPflash分析）。了解更多

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iCRT 14

Catalog No. A16218
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CRT 抑制剂

iCRT 14是一种新型的有效的β-catenin反应转录（CRT）抑制剂（在Wnt途径活性测定中IC50 = 40.3 nM）。了解更多

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Hexachlorophene

Catalog No. A16217
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Wnt/beta-catenin 抑制剂

Hexachlorophene是一种有效的KCNQ1/KCNE1钾通道激活剂，EC50为4.61±1.29 uM。也是Wnt/β-catenin信号的抑制剂。了解更多

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IQ-1

Catalog No. A16064
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Wnt/beta-catenin 抑制剂

IQ-1是可透过细胞的四氢异喹啉亚基化合物，可调节Wnt/β-catenin信号传导。了解更多

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BC2059

Catalog No. A14381
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beta-catenin inhibitor

BC2059 is an orally bioavailable and potent beta-catenin inhibitor. 了解更多

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- Ji-Hye Jung, .et al. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities, Stem Cells Dev, 2016, Jul 1; 25(13): 1006-1019 PMID: 27188501
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WAY-316606

Catalog No. A13986
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sFRP-1 抑制剂

WAY-316606是分泌蛋白sFRP-1的小分子抑制剂，sFRP-1是分泌糖蛋白Wnt的内源性拮抗剂。了解更多

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FH535

Catalog No. A13795
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β-Catenin/Tcf 抑制剂

FH535是Wnt/β-catenin和PPAR的抑制剂，具有抗肿瘤活性。了解更多

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- Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
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IWR-1-endo

Catalog No. A12737
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Wnt 抑制剂

IWR-1-endo是Wnt应答的有效抑制剂，可阻断基于细胞的Wnt /β-catenin途径报道分子应答，IC50值为180 nM。 Wnt蛋白与细胞表面的受体结合，启动信号级联反应，从而导致β-catenin激活基因转录。了解更多

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- Charles A.Herring, .et al. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921
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ICG-001

Catalog No. A11039
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Wnt/beta-catenin 抑制剂

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。了解更多

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- Seonmin Choi, .et al. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors, Yonsei Med J, 2021, Nov;62(11):1042-1051 PMID: 34672138
- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536