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c-MET

Inhibitory Selectivity

Catalog No.Inhibitor Name c-MetOther
A10712Crizotinib
*
ALK
A10996Cabozantinib
***
VEGFR2/KDR,Kit,VEGFR3/FLT4
A10998Foretinib
****
KDR,Tie-2,VEGFR3/FLT4
A10713PHA-665752
**
RON,Flk1,c-Abl
A10869SU11274
**
Flk1,RON,FGFR1
A10839SGX-523
***
A10153BMS-777607
***
Axl,RON,Tyro3
A11087Tivantinib
*
A10493JNJ-38877605
***
A10711PF-04217903
**
A10587MGCD-265
****
RON,VEGFR2,VEGFR1
A11132Capmatinib
****
A11059BMS-754807
**
Insulin Receptor,IGF-1R,TrkB
A10154BMS-794833
***
VEGFR2
A10063AMG-208
**
A11753MK-2461
****
c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
A11396Golvatinib
*
VEGFR2
A11055AMG-458
****
VEGFR2
A11257Tepotinib
***
IRAK4,TrkA,Axl
A11150NVP-BVU972
*
A12557Merestinib
***
A15917NPS-1034
*
Axl
A11489MK-8033
****
Ron
A14387Altiratinib
***
TIE-2, VEGFR
A14419Volitinib (Savolitinib, AZD-6094)
A15792BMS-817378
***
VEGFR2

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

35 个项目

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  1. LY2801653 dihydrochloride
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    LY2801653 dihydrochloride

    Catalog No. A15150
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    MET 抑制剂
    LY2801653 dihydrochloride是一种有效的，口服可生物利用的c-MET激酶小分子抑制剂（Ki = 2 nM）。 了解更多
  2. PF-04217903 methanesulfonate
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    PF-04217903 methanesulfonate

    Catalog No. A15208
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    c-Met 抑制剂
    PF-04217903 methanesulfonate是一种选择性ATP竞争性c-Met抑制剂，IC50为4.8 nM，易致癌突变（对Y1230C突变体无活性）。 了解更多
  3. BMS-817378
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    BMS-817378

    Catalog No. A15792
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    MET/VEGFR-2 抑制剂
    BMS-817378是Met/VEGFR-2双重抑制剂BMS-794833的新型前药。 了解更多
  4. INCB28060
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    INCB28060

    Catalog No. A11132
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    c-MET 抑制剂
    INCB28060 (Capmatinib )是一种新型的，ATP竞争性c-MET抑制剂，无细胞试验中IC50为0.13 nM，对RONβ，EGFR和HER-3无活性。 了解更多
  5. Altiratinib (DCC2701)
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    Altiratinib (DCC2701)

    Catalog No. A14387
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    c-Met/VEGFR 抑制剂
    Altiratinib (DCC2701)是一种新型的c-MET/TIE-2/VEGFR抑制剂；与体外HGF拮抗剂相比，可有效降低体内的肿瘤负荷并阻断c-MET pTyr（1349）介导的信号传导，细胞生长和迁移。 了解更多
  6. ARQ 197 (Tivantinib)
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    ARQ 197 (Tivantinib)

    Catalog No. A11087
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    c-Met 抑制剂
    ARQ-197是c-Met受体酪氨酸激酶的选择性抑制剂, 在无细胞试验中Ki为0.355 μM，对Ron几乎没有作用活性，对EGFR， InsR， PDGFRα和FGFR1/4没有抑制作用。 了解更多
  7. BMS-754807
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    BMS-754807

    Catalog No. A11059
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    IGF-1R 抑制剂
    BMS-754807是一种有效的，口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。 了解更多
  8. NPS-1034
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    NPS-1034

    Catalog No. A15917
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    c-Met 抑制剂
    NPS-1034是双重Met/Axl抑制剂，IC50分别为48 nM和10.3 nM。 了解更多
  9. LY2801653 (Merestinib)
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    LY2801653 (Merestinib)

    Catalog No. A12557
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    c-MET 抑制剂
    LY2801653 (Merestinib)是一种有效的，口服生物利用的小分子c-MET激酶抑制剂（Ki = 2 nM）。 了解更多
  10. c-Met inhibitor 2
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    c-Met inhibitor 2

    Catalog No. A16256
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    c-Met 抑制剂
    c-Met inhibitor 2 是有效的化合物，对依赖于Met激活的癌症具有活性，并且还具有作为VEGFR抑制剂的抗癌活性。 了解更多
  11. Glesatinib hydrochloride
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    Glesatinib hydrochloride

    Catalog No. A16257
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    MET/Axl 抑制剂
    Glesatinib hydrochloride是MET和Axl受体酪氨酸激酶途径的抑制剂，当改变时，它们会驱动肿瘤的生长。 了解更多
  12. Foretinib (GSK1363089, XL880)
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    Foretinib (GSK1363089, XL880)

    Catalog No. A10998
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    c-MET 抑制剂
    Foretinib (GSK1363089,XL880)是c-Met和VEGFR-2的多激酶抑制剂，可抑制增殖，诱导Anoikis并损害卵巢癌转移。 了解更多
  13. XL184 free base (Cabozantinib)
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    XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR 抑制剂
    XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。 了解更多
  14. PF-2341066 (Crizotinib)
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    PF-2341066 (Crizotinib)

    Catalog No. A10712
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    ALK/ c-Met 抑制剂
    PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖（IC50 = 30 nM）。 了解更多
  15. AMG 337
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    AMG 337

    Catalog No. A16400
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    MET 抑制剂
    AMG 337是MET受体的口服，小分子，ATP竞争性，高选择性抑制剂。 了解更多
  16. MK-8033
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    MK-8033

    Catalog No. A11489
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    c-Met 抑制剂
    MK-8033是一种新的特异性ATP竞争性c-Met/Ron双重抑制剂 ，对野生型c-Met的IC50为1 nM，对c-Met N1100Y的IC50为2.0 nM。 了解更多
  17. Glumetinib (SCC-244)
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    Glumetinib (SCC-244)

    Catalog No. A18328
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    c-Met inhibitor
    Glumetinib (SCC244) is a potent and highly selective c-Met kinase inhibitor with an IC50 of 0.42 nM. Glumetinib shows antitumor activity and a superior safety margin. 了解更多
  18. JNJ-38877618
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    JNJ-38877618

    Catalog No. A18325
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    c-Met inhibitor
    JNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. 了解更多
  19. S49076
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    S49076

    Catalog No. A21407
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    MET, AXL/MER, and FGFR1/2/3 inhibitor
    S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM. 了解更多
  20. BMS 777607
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    BMS 777607

    Catalog No. A21638
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    c-Met/Axl/Ron/Tyro3 inhibitor
    BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. 了解更多
  21. c-Met inhibitor 1
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    c-Met inhibitor 1

    Catalog No. A15049
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    c-Met 抑制剂
    c-Met inhibitor 1 是c-Met受体信号传导途径的抑制剂，可作用于胃癌，胶质母细胞瘤和胰腺癌在内的癌症。 了解更多
  22. Volitinib (Savolitinib, AZD-6094)
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    Volitinib (Savolitinib, AZD-6094)

    Catalog No. A14419
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    c-Met 抑制剂
    Volitinib (Savolitinib,AZD-6094)是c-Met受体酪氨酸激酶的生物利用抑制剂，具有潜在的抗肿瘤活性。 了解更多
  23. MK-2461
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    MK-2461

    Catalog No. A11753
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    c-Met 抑制剂
    MK-2461是一种新型的多靶点激酶抑制剂，优先抑制活化的c-Met受体。 了解更多
  24. EMD-1214063
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    EMD-1214063

    Catalog No. A11257
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    c-Met 抑制剂
    EMD-1214063是MET酪氨酸激酶的抑制剂，IC50为4 nM，作用于c-Met比作用于IRAK4， TrkA， Axl， IRAK1和Mer选择性高200倍以上。具有潜在的抗肿瘤活性。它与MET酪氨酸激酶结合并破坏MET信号转导途径，这可能在过表达该激酶的肿瘤细胞中诱导凋亡。 了解更多
  25. NVP-BVU972
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    NVP-BVU972

    Catalog No. A11150
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    C-Met 抑制剂
    NVP-BVU972是一种选择性的MET抑制剂。 了解更多
  26. AMG-458
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    AMG-458

    Catalog No. A11055
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    c-Met 抑制剂
    AMG-458是一种有效的c-Met抑制剂，IC50值为60nM，对VEGFR2具有选择性。 了解更多
  27. BMS-794833
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    BMS-794833

    Catalog No. A10154
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    c-Met 抑制剂
    BMS-794833是Met和VEGFR-2的有效ATP竞争性抑制剂，IC50为1.7和15 nM。 了解更多
  28. AMG 208
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    AMG 208

    Catalog No. A10063
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    c-Met 抑制剂
    AMG 208是一种新型c-Met抑制剂，可抑制c-Met的配体依赖性和配体依赖性活化，从而抑制其酪氨酸激酶活性。 了解更多
  29. PF-04217903
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    PF-04217903

    Catalog No. A10711
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    c-Met 抑制剂
    PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。 了解更多
  30. MGCD-265 (Glesatinib)
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    MGCD-265 (Glesatinib)

    Catalog No. A10587
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    c-Met 抑制剂
    MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。 了解更多
  31. BMS-777607
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    BMS-777607

    Catalog No. A10153
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    c-Met 抑制剂
    BMS-777607是一种MET酪氨酸激酶抑制剂，与c-Met蛋白或HGFR结合，可防止HGF结合并破坏MET信号通路。 了解更多
  32. JNJ-38877605
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    JNJ-38877605

    Catalog No. A10493
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    c-Met 抑制剂
    JNJ-38877605是一种ATP竞争性的c-Met抑制剂，从而抑制c-Met磷酸化并破坏c-Met信号转导途径。 了解更多
  33. SGX-523
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    SGX-523

    Catalog No. A10839
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    c-Met 抑制剂
    SGX-523是一种口服生物可利用的小分子，与c-Met蛋白或HGFR特异性结合，可防止HGF结合并破坏MET信号通路。 了解更多
  34. PHA-665752
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    PHA-665752

    Catalog No. A10713
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    c-Met 抑制剂
    PHA665752是c-Met/HGF/SF信号传导的小分子抑制剂。 了解更多
  35. SU11274
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    SU11274

    Catalog No. A10869
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    c-Met 抑制剂
    SU11274是一种Met酪氨酸激酶抑制剂。 了解更多

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