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Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. 了解更多 -
AZD5423
Catalog No. A13249 -
Timosaponin b-II
Catalog No. A14591 -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 抑制剂Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多 -
BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
BMS 433796
Catalog No. A11337 -
E 2012
Catalog No. A11393 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
Flurizan
Catalog No. A12433 -
LY3039478
Catalog No. A13544 -
gamma-secretase modulator 3
Catalog No. A15090 -
Compound W
Catalog No. A15296 -
JLK 6
Catalog No. A15301 -
PF-03084014
Catalog No. A11259 -
Flurbiprofen Axetil
Catalog No. A13662 -
L-685458
Catalog No. A15899 -
Begacestat (GSI-953)
Catalog No. A11258 -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多 -
gamma-secretase modulator 2
Catalog No. A11427 -
TC-E 5006
Catalog No. A13217 -
CHF5074
Catalog No. A16214 -
Z-Ile-Leu-aldehyde
Catalog No. A16215 -
IMR-1A
Catalog No. A16223 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
Compound E
Catalog No. A21292 -
alpha-Amyloid Precursor Protein Modulator
Catalog No. A13094 α-淀粉样前体蛋白调节剂是细胞可渗透的苯并内酰胺衍生的PKC激活剂（PKCα的Ki = 11.9 nM），即使在人类原纤维中为100 nM时，也能有效增强淀粉样前体蛋白（APP）的非淀粉样生成性α-加工。 了解更多 -
Amyloid b-Peptide (1-42) (human)
Catalog No. A14075 Amyloid β-Peptide (1-42) human是由淀粉样蛋白前体蛋白加工而成的36-C43个氨基酸的肽。Amyloid β-Peptide (1-42) human是一种42个氨基酸的肽，在阿尔茨海默病的发病机理中起关键作用。 了解更多 -
Amyloid b-peptide (42-1) (human)
Catalog No. A15414 Amyloid b-peptide (42-1) (human)，淀粉样蛋白b（1-42）肽的无活性对照。 了解更多 -
Amyloid b-Peptide (10-20) (human)
Catalog No. A15415 Amyloid b-Peptide (10-20) (human)，可溶性淀粉样蛋白b肽片段，是明胶酶A/IV型胶原酶/MMP-2和APP分泌??酶的底物；在Lys16和Leu17之间分裂。 了解更多 -
Amyloid b-peptide (25-35) (human)
Catalog No. A15416 Amyloid b-peptide (25-35) (human)，是人淀粉样蛋白β肽的片段，在功能上是与阿尔茨海默氏病相关的神经营养作用和神经毒性作用。 了解更多 -
Amyloid b-Peptide (12-28) (human)
Catalog No. A15417 Amyloid b-Peptide (12-28) (human)，淀粉样蛋白b肽片段;结合脑蛋白所需的最小截面。 了解更多
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- β-Amyloid (21)
- γ-Secretase (34)
- Beta-secretase (BACE) (14)
- COX (64)
- GABA Receptors (55)
- NMDA Receptors (40)
- CaMK (17)
- AChE (21)
- mAChR (50)
- nAChR (24)
- P2X Receptor (14)
- Purinergic (P2Y) Receptors (13)
- GlyT (5)
- 作用机制
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- Inhibitor (抑制剂) (159)
- Agonist (激动剂) (41)
- Antagonist (拮抗剂) (86)
- Activator (激活剂) (4)
- Modulator (调节剂) (29)
- Blocker (阻断剂) (3)
- Inducer (诱导剂) (1)
- Potentiator (增强剂) (2)
- 靶点
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- 5-lipoxygenase (1)
- COX (13)
- COX-1 (13)
- COX-2 (23)
- Histamine H1 receptor (1)
- HSP90 (1)
- LOX (1)
- Src (1)
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