PDK1

Inhibitory Selectivity

Catalog No.	Inhibitor Name	PDK-1	Other Targets
A10681	OSU-03012	**
A11148	BX-795	****	TBK1/IKKɛ,c-Kit,CDK2/CyclinE
A11149	BX-912	***	PKA,KDR,CDK2/CyclinE
A11032	PHT-427	*	Akt
A12767	GSK2334470	***
A12881	BX-517	****
A11511	NVP-BAG956	*	PI3K
A13484	PS 48	*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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BX-795

Catalog No. A11148
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PDK-1 抑制剂

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。了解更多

Product Citations (1)

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- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
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PDK1 inhibitor

Catalog No. A11528
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PDK1 抑制剂

PDK1 inhibitor是PDK1的有效和选择性抑制剂，具有作为抗癌剂的潜力。了解更多

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PDK1 inhibitor

Catalog No. A16185
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PDK1 抑制剂

PDK1 inhibitor，强效，ATP竞争性和选择性双重PI3K和PDPK1抑制剂（PDK1和p-T308-PKB抑制的IC50值分别为34 nM和94 nM。了解更多

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PHT-427

Catalog No. A11032
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AKT 抑制剂

PHT-427是一种新型的Akt/磷脂酰肌醇依赖性蛋白激酶1 pleckstrin同源域抑制剂。了解更多

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OSU-03012

Catalog No. A10681
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PDK-1 抑制剂

OSU-03012 (AR-12)是一种有效的重组PDK-1(phosphoinositide-dependent kinase 1)抑制剂。了解更多

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BX-912

Catalog No. A11149
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PDK1 抑制剂

BX-912是3-磷酸肌醇依赖性激酶1（PDK1）的抑制剂。了解更多

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NVP-BAG956

Catalog No. A11511
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PI3K/PDK-1 抑制剂

NVP-BAG956是一种强效、可逆和ATP竞争性PI3-K/PDK1双激酶抑制剂，对VEGFR 1(IC50 = 2.56 μM)的效力大大降低，对其他15种激酶(IC50 > 10 uM)的活性很小或没有活性。了解更多

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GSK 2334470

Catalog No. A12767
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PDK1 抑制剂

GSK 2334470是一种有效的3-磷酸肌醇依赖性蛋白激酶（PDK1）抑制剂（IC50?10 nM）。了解更多

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BX-517

Catalog No. A12881
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PDK1 抑制剂

BX-517是一种有效且选择性的PDK1抑制剂，可与蛋白质的ATP结合袋结合（IC50 = 6 nM）。了解更多

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KPLH1130

Catalog No. A18494
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PDK inhibitor

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice. 了解更多

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