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￥ 0.00 PI3K / Akt / mTOR
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PS 48
Catalog No. A13484 -
BX-517
Catalog No. A12881 -
KU 0060648
Catalog No. A13224 DNA-PK 抑制剂KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。 了解更多 -
Compound 401
Catalog No. A11778 DNA-PK 抑制剂Compound 401是一种细胞可渗透的嘧啶-异喹啉酮化合物，可作为有效的，可逆的和ATP竞争的DNA-PK抑制剂（IC50 = 280 nM），选择性是mTOR（IC50 = 5.3μM）的19倍。 了解更多 -
NU6027
Catalog No. A14136 -
Nedisertib
Catalog No. A17055 DNA-PK 抑制剂Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶（DNA-PK）抑制剂，具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多 -
(Rac)-Nedisertib
Catalog No. A21383 DNA-PK inhibitor(Rac)-Nedisertib ((Rac)-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM. 了解更多 -
PF 4708671
Catalog No. A11755 S6 kinase 抑制剂PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。 了解更多 -
LJH685
Catalog No. A14372 -
LJI308
Catalog No. A14373 -
LY-2584702 tosylate salt
Catalog No. A15527 p70S6K 抑制剂LY-2584702 tosylate salt是p70S6K信号传导抑制剂。抑制p70S6K并阻止核糖体S6亚基的磷酸化。 了解更多 -
LY-2584702
Catalog No. A14202 -
AR-A 014418
Catalog No. A13728 GSK-3 抑制剂AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。 了解更多 -
BIO-acetoxime
Catalog No. A15555 GSK-3 抑制剂BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。 了解更多 -
Indirubin-3-monoxime
Catalog No. A16280 GSK-3β 抑制剂Indirubin-3'-monoxime是一种功能强大的GSK-3β抑制剂，IC50为22nM，也抑制CDK1/5（IC50 = 180/100 nM）。 了解更多 -
CHIR-98014
Catalog No. A11085 -
TWS119
Catalog No. A11223 -
Tideglusib
Catalog No. A11592 GSK-3 抑制剂Tideglusib是一种不可逆的，非ATP竞争性的GSK-3β抑制剂，无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。 了解更多 -
AZD2858
Catalog No. A13060 -
1-Azakenpaullone
Catalog No. A14303 GSK-3β 抑制剂1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。 了解更多 -
IM-12
Catalog No. A14196 -
Bikinin
Catalog No. A15526 -
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最新产品
BIO
Catalog No. A17129 -
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VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. 了解更多 -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. 了解更多 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
GSK-3 inhibitor 1
Catalog No. A21803 -
A-769662
Catalog No. A11071 -
Acadesine (Aicar,NSC 105823)
Catalog No. A10028 AMPK 激活剂Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。 了解更多 -
BML-275 (Dorsomorphin)
Catalog No. A11970 AMPK 抑制剂BML-275 (Dorsomorphin)是一种可渗透细胞的吡唑并嘧啶化合物，显示为AMP激活的蛋白激酶（AMPK）和脂肪酸合酶抑制剂。 了解更多 -
Dorsomorphin 2HCl
Catalog No. A13720 BMP 抑制剂Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂，可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。 了解更多
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