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PI3K / Akt / mTOR

产品 151 到 200 共 280个

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  1. CAL-130 Racemate
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    CAL-130 Racemate

    Catalog No. A20942
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    PI3Kδ inhibitor
    CAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor. 了解更多
  2. Alpelisib hydrochloride
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    Alpelisib hydrochloride

    Catalog No. A21794
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    PI3Kα inhibitor
    Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. 了解更多
  3. Umbralisib R-enantiomer
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    Umbralisib R-enantiomer

    Catalog No. A21993
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    PI3Kδ inhibitor
    Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. 了解更多
  4. GSK2292767
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    GSK2292767

    Catalog No. A16564
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    PI3Kδ inhibitor
    GSK2292767 is a potent and selective inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ; Ki = 79 pM). GSK2292767 is >100-fold selective for PI3Kδ over a panel of 250 kinases. 了解更多
  5. PQR-530
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    PQR-530

    Catalog No. A19209
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    dual pan-PI3K/mTORC1/2 inhibitor
    PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. 了解更多
  6. PI3Kdelta inhibitor 1
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    PI3Kdelta inhibitor 1

    Catalog No. A19249
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    PI3Kδ inhibitor
    PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM. 了解更多
  7. GDC-0077
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    GDC-0077

    Catalog No. A19494
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    PI3Kα inhibitor
    GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). 了解更多
  8. CHMFL-PI3KD-317
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    CHMFL-PI3KD-317

    Catalog No. A19990
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    PI3Kδ inhibitor
    CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM. 了解更多
  9. NSC781406
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    NSC781406

    Catalog No. A20402
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    PI3K/mTOR inhibitor
    NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα. 了解更多
  10. GDC-0326
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    GDC-0326

    Catalog No. A20437
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    PI3Kα inhibitor
    GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. 了解更多
  11. SF2523
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    SF2523

    Catalog No. A20557
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    PI3K inhibitor
    SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively. 了解更多
  12. PI3K-IN-6
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    PI3K-IN-6

    Catalog No. A20687
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    PI3K β/δ inhibitor
    PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. 了解更多
  13. LAS191954
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    LAS191954

    Catalog No. A20691
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    PI3Kδ inhibitor
    LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM. 了解更多
  14. SRX3207
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    SRX3207

    Catalog No. A22305
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    Syk/PI3K inhibitor
    SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression. 了解更多
  15. Everolimus (RAD001)
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    Everolimus (RAD001)

    Catalog No. A10374
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    mTOR 抑制剂
    Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。 了解更多
  16. AZD8055
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    AZD8055

    Catalog No. A10114
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    mTOR 抑制剂
    AZD8055是一种有效的，选择性的ATP竞争性mTOR激酶抑制剂，IC50为0.8 nM。 了解更多
  17. Rapamycin (Sirolimus)
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    Rapamycin (Sirolimus)

    Catalog No. A10782
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    mTOR 抑制剂
    Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2（IL-2）的反应来防止其活化。 了解更多
  18. Torin 1
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    Torin 1

    Catalog No. A11587
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    mTOR 抑制剂
    Torin1是mTOR的有效抑制剂，IC50为2-10 nM。 了解更多
  19. PP242 (Torkinib)
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    PP242 (Torkinib)

    Catalog No. A10746
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    mTOR 抑制剂
    PP242 (Torkinib)在mTORC1和mTORC2中都是有效的选择性mTOR抑制剂。 了解更多
  20. WYE-354
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    WYE-354

    Catalog No. A10989
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    mTOR 抑制剂
    WYE-354是一种有效的mTOR细胞渗透抑制剂（IC50 = 4.3 nM），可阻断通过mTOR复合体1（mTORC1）和mTORC2的信号传导。它是PI3Kα（IC50 = 1026 nM）和其他激酶的弱得多的抑制剂。 了解更多
  21. FK-506 (Tacrolimus)
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    FK-506 (Tacrolimus)

    Catalog No. A10389
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    mTOR 抑制剂
    FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。 了解更多
  22. AZD2014 (Vistusertib)
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    AZD2014 (Vistusertib)

    Catalog No. A11303
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    mTORC1/2 抑制剂
    Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。 了解更多
  23. mTOR inhibitor (mTOR-IN-1)
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    mTOR inhibitor (mTOR-IN-1)

    Catalog No. A15175
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    mTOR 抑制剂
    mTOR inhibitor (mTOR-IN-1)是mTOR的有效且选择性的ATP竞争性抑制剂，Ki为1.5 nM。 了解更多
  24. MHY1485
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    MHY1485

    Catalog No. A15508
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    mTOR 抑制剂
    MHY1485是mTOR激活剂；通过抑制自噬体和溶酶体之间的融合导致LC3II蛋白的积累和自噬体扩大，从而抑制自噬过程。 了解更多
  25. QL-IX-55
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    QL-IX-55

    Catalog No. A11537
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    mTORC1/2 抑制剂
    QL-IX-55是mTORC1/2的选择性ATP竞争性抑制剂，其IC50分别为50/50/10-50nM，用于人mTORC1/酵母mTORC1/酵母mTORC2。 了解更多
  26. Temsirolimus (Torisel)
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    Temsirolimus (Torisel)

    Catalog No. A10906
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    mTOR 抑制剂
    Temsirolimus (Torisel)是mTOR的特异性抑制剂，会干扰调节肿瘤细胞增殖，生长和存活的蛋白质的合成。 了解更多
  27. KU-0063794
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    KU-0063794

    Catalog No. A10505
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    mTOR 抑制剂
    KU-0063794是哺乳动物雷帕霉素靶位的选择性抑制剂(分别为mTORC1和mTORC2，IC50 ~10 nM)。 了解更多
  28. WYE-125132 (WYE-132)
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    WYE-125132 (WYE-132)

    Catalog No. A11038
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    mTOR 抑制剂
    WYE-125132 (WYE-132)是一种高度有效的，ATP竞争性的mTOR抑制剂，IC50为0.19 nM；作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。 了解更多
  29. OSI-027
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    OSI-027

    Catalog No. A11056
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    mTOR 抑制剂
    OSI-027是一种有效的，选择性的，可口服生物利用的mTOR激酶抑制剂，可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。 了解更多
  30. WYE-687
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    WYE-687

    Catalog No. A11187
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    mTOR 抑制剂
    WYE-687是雷帕霉素（mTOR）哺乳动物靶标的新型ATP竞争性和选择性抑制剂，IC50为7 nM；抑制mTORC1/pS6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)，作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  31. WAY-600
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    WAY-600

    Catalog No. A11188
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    mTOR 抑制剂
    WAY-600是一种有效的，ATP竞争性的，选择性的mTOR抑制剂，IC50为9 nM；抑制mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)；作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  32. Deforolimus (Ridaforolimus)
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    Deforolimus (Ridaforolimus)

    Catalog No. A10295
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    mTOR 抑制剂
    Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。 了解更多
  33. INK 128 (MLN0128)
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    INK 128 (MLN0128)

    Catalog No. A11461
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    mTOR 抑制剂
    INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。 了解更多
  34. GDC-0349
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    GDC-0349

    Catalog No. A11443
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    mTOR 抑制剂
    GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。 了解更多
  35. Zotarolimus
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    Zotarolimus

    Catalog No. A11950
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    mTOR 抑制剂
    Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。 了解更多
  36. Torin 2
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    Torin 2

    Catalog No. A11586
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    mTOR 抑制剂
    Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。 了解更多
  37. XL388
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    XL388

    Catalog No. A12395
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    mTOR 抑制剂
    XL388是哺乳动物雷帕霉素靶标(mTOR)的一类新型高效、选择性、ATP竞争性生物可利用抑制剂。 了解更多
  38. AP1903
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    AP1903

    Catalog No. A13519
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    AP1903是具有均二聚活性的脂质渗透性他克莫司类似物。二聚体药物AP1903将人类蛋白质FKBP12（Fv）的类似物同二聚化，该类似物包含单个酸取代（Phe36Val），因此AP1903以低1000倍的亲和力与野生型FKBP12结合。 了解更多
  39. CC-115
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    CC-115

    Catalog No. A15779
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    mTOR/DNA-PK 抑制剂
    CC-115是mTOR/DNA-PK的抑制剂（IC50 = 21/13 nM）。 了解更多
  40. CC-223
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    CC-223

    Catalog No. A13078
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    mTOR 抑制剂
    CC-223是一种有效的mTOR激酶抑制剂（IC50 = 16 nM），其敏感性是相关脂质激酶PI3K-alpha（IC50 = 4 uM）的> 150倍。 了解更多
  41. CZ415
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    CZ415

    Catalog No. A16476
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    mTOR inhibitor
    CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex. 了解更多
  42. mTOR inhibitor-2
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    mTOR inhibitor-2

    Catalog No. A13035
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    mTOR inhibitor
    mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates. 了解更多
  43. HDACs/mTOR Inhibitor 1
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    HDACs/mTOR Inhibitor 1

    Catalog No. A13462
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    HDACs/mTOR Inhibitor 1
    HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. 了解更多
  44. 42-(2-Tetrazolyl)rapamycin
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    42-(2-Tetrazolyl)rapamycin

    Catalog No. A21394
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    mTOR inhibitor
    42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. 了解更多
  45. BX-795
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    BX-795

    Catalog No. A11148
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    PDK-1 抑制剂
    BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。 了解更多
  46. PDK1 inhibitor
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    PDK1 inhibitor

    Catalog No. A11528
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    PDK1 抑制剂
    PDK1 inhibitor是PDK1的有效和选择性抑制剂，具有作为抗癌剂的潜力。 了解更多
  47. PDK1 inhibitor
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    PDK1 inhibitor

    Catalog No. A16185
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    PDK1 抑制剂
    PDK1 inhibitor，强效，ATP竞争性和选择性双重PI3K和PDPK1抑制剂（PDK1和p-T308-PKB抑制的IC50值分别为34 nM和94 nM。 了解更多
  48. OSU-03012
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    OSU-03012

    Catalog No. A10681
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    PDK-1 抑制剂
    OSU-03012 (AR-12)是一种有效的重组PDK-1(phosphoinositide-dependent kinase 1)抑制剂。 了解更多
  49. BX-912
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    BX-912

    Catalog No. A11149
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    PDK1 抑制剂
    BX-912是3-磷酸肌醇依赖性激酶1（PDK1）的抑制剂。 了解更多
  50. GSK 2334470
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    GSK 2334470

    Catalog No. A12767
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    PDK1 抑制剂
    GSK 2334470是一种有效的3-磷酸肌醇依赖性蛋白激酶（PDK1）抑制剂（IC50?10 nM）。 了解更多

产品 151 到 200 共 280个

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分类
  1. Akt (43)
  2. PI3K (124)
  3. mTOR (54)
  4. PDK1 (12)
  5. DNA-PK (14)
  6. RSK (13)
  7. GSK-3 (25)
  8. AMPK (15)
  9. MELK (4)
  10. ATM / ATR (20)
作用机制
  1. Inhibitor (抑制剂) (249)
  2. Activator (激活剂) (14)
靶点
  1. AKT1 (8)
  2. AKT2 (7)
  3. AKT3 (5)
  4. DNA-PK (1)
  5. HDAC1 (1)
  6. HDAC10 (1)
  7. HDAC11 (1)
  8. HDAC2 (1)
  9. HDAC3 (1)
  10. HDAC6 (1)
  11. p110α (7)
  12. p110β (3)
  13. p110γ (3)
  14. p110δ (3)
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