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Proteases

产品 251 到 292 共 292个

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  1. JLK 6
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    JLK 6

    Catalog No. A15301
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    γ-secretase 抑制剂
    JLK 6是γ-分泌酶的抑制剂，可选择性抑制APP裂解而不影响其他γ-分泌酶介导的途径。 了解更多
  2. MRK 560
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    MRK 560

    Catalog No. A15304
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    γ-secretase 抑制剂
    MRK 560是一种可用的γ-分泌酶抑制剂，能够显着减少大鼠脑和CSF中的Abeta肽，并证实该大鼠可用于评估γ-分泌酶抑制剂对中枢神经系统Abeta的作用（40）体内水平。 了解更多
  3. PF-03084014
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    PF-03084014

    Catalog No. A11259
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    γ-secretase 抑制剂
    PF-03084014是一种可逆和选择性的γ-分泌酶抑制剂，IC50值为6.2 nM。 了解更多
  4. Flurbiprofen Axetil
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    Flurbiprofen Axetil

    Catalog No. A13662
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    gamma-secretase 抑制剂
    Flurbiprofen Axetil是非甾体抗炎药(NSAID)。 了解更多
  5. L-685458
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    L-685458

    Catalog No. A15899
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    γ-secretase 抑制剂
    L-685458是一种有效的A beta PPγ-分泌酶抑制剂，Ki为17 nM。 了解更多
  6. Begacestat (GSI-953)
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    Begacestat (GSI-953)

    Catalog No. A11258
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    γ-secretase 抑制剂
    Begacestat (GSI-953)是一种新型的选择性淀粉样前体蛋白γ-分泌酶的噻吩磺酰胺抑制剂。 了解更多
  7. Verubecestat (MK-8931)
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    Verubecestat (MK-8931)

    Catalog No. A16113
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    β-secretase/BACE1 抑制剂
    Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多
  8. Z-Ile-Leu-aldehyde
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    Z-Ile-Leu-aldehyde

    Catalog No. A16215
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    γ-Secretase 抑制剂
    Z-Ile-Leu-aldehyde是一种有效的γ-分泌酶抑制剂；Notch信号抑制剂。 了解更多
  9. BACE1-IN-4
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    BACE1-IN-4

    Catalog No. A18462
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    BACE1 inhibitor
    BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多
  10. PF-06751979
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    PF-06751979

    Catalog No. A20066
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    BACE1 inhibitor
    PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多
  11. Umibecestat (CNP520)
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    Umibecestat (CNP520)

    Catalog No. A18987
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    BACE-1 inhibitor
    Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多
  12. Lanabecestat
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    Lanabecestat

    Catalog No. A12282
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    BACE1 inhibitor
    Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多
  13. BACE1-IN-1
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    BACE1-IN-1

    Catalog No. A12183
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    BACE1 inhibitor
    BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多
  14. BMS-906024
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    BMS-906024

    Catalog No. A21172
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    gamma secretase inhibitor
    BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多
  15. Compound E
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    Compound E

    Catalog No. A21292
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    γ-secretase inhibitor
    Compound E is a γ-secretase inhibitor. 了解更多
  16. β-Secretase Inhibitor IV
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    β-Secretase Inhibitor IV

    Catalog No. A21346
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    BACE-1 inhibitor
    β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多
  17. AZD3839 free base
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    AZD3839 free base

    Catalog No. A21606
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    BACE1 inhibitor
    AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多
  18. Z-FA-FMK
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    Z-FA-FMK

    Catalog No. A14284
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    Irreversible Cysteine Protease 抑制剂
    Z-FA-FMK是不可逆的半胱氨酸蛋白酶抑制剂。 了解更多
  19. Boc-D-FMK
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    Boc-D-FMK

    Catalog No. A15392
    Caspase 抑制剂
    BOC-D-FMK是Caspase-3的新型抑制剂。 了解更多
  20. Emricasan
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    Emricasan

    Catalog No. A11394
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    Caspase inhibitor
    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. 了解更多
  21. Z-YVAD-FMK
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    Z-YVAD-FMK

    Catalog No. A16317
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    Caspase-1 抑制剂
    Z-YVAD-FMK是有效的细胞渗透性和caspase-1不可逆抑制剂。 了解更多
  22. Z-VAD(OH)-FMK
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    Z-VAD(OH)-FMK

    Catalog No. A16340
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    Caspase 抑制剂
    Z-VAD(OH)-FMK是所有胱天蛋白酶的不可逆三肽抑制剂。 了解更多
  23. Z-FA-FMK
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    Z-FA-FMK

    Catalog No. A16381
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    Cysteine protease 抑制剂
    Z-FA-FMK是半胱氨酸蛋白酶的不可逆抑制剂。 了解更多
  24. MX1013
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    • 最新产品

    MX1013

    Catalog No. A17218
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    pan-caspase inhibitor
    MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9. 了解更多
  25. VX-765 (Belnacasan)
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    VX-765 (Belnacasan)

    Catalog No. A10984
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    Caspase-1/4 抑制剂
    VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂，是一种控制两种细胞因子IL-1b和IL-18生成的酶。 了解更多
  26. Z-VAD-FMK
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    Z-VAD-FMK

    Catalog No. A12373
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    Pan Caspase 抑制剂
    Z-VAD-FMK是一种细胞可渗透、不可逆的泛胱天蛋白酶抑制剂。体外抑制肿瘤细胞caspase加工和凋亡诱导(IC50 = 0.0015 - 5.8 mM)。活跃在体内。 了解更多
  27. Nivocasan (GS-9450)
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    Nivocasan (GS-9450)

    Catalog No. A14100
    Caspase 抑制剂
    Nivocasan (GS-9450)是一种新型的caspase抑制剂，已在纤维化/凋亡动物模型中证明了其肝保护活性。 了解更多
  28. Z-DEVD-FMK
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    Z-DEVD-FMK

    Catalog No. A13503
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    Caspase-3 抑制剂
    Z-DEVD-FMK是一种特殊的不可逆的Caspase-3抑制剂。 了解更多
  29. Z-LEHD-FMK
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    Z-LEHD-FMK

    Catalog No. A14358
    Caspase-9 抑制剂
    Z-LEHD-FMK是一种不可逆抑制caspase-9和相关caspase活性的合成肽。 了解更多
  30. Q-VD-OPh hydrate
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    Q-VD-OPh hydrate

    Catalog No. A14915
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    Caspase 抑制剂
    Q-VD-OPh hydrate是一种选择性，脑和细胞可渗透的，高效且不可逆的caspase-3（IC50 = 25nm），caspase-1（IC50 = 50nM），caspase-8（IC50 = 100nM）和caspase-9抑制剂 （IC50 ＝ 430nM）。 了解更多
  31. Z-WEHD-FMK
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    Z-WEHD-FMK

    Catalog No. A14916
    Caspase 抑制剂
    Z-WEHD-FMK是不可逆抑制caspase-5和相关caspase活性的合成肽。 了解更多
  32. Caspase-3/7 Inhibitor I
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    Caspase-3/7 Inhibitor I

    Catalog No. A14919
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    Caspase-3/7 抑制剂
    Caspase-3/7 Inhibitor I是caspase-3（Ki = 60 nM）和caspase-7（Ki = 170 nM）的有效，细胞可渗透且可逆的有效抑制剂。 了解更多
  33. AZ 10417808
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    AZ 10417808

    Catalog No. A15294
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    Caspase-3 抑制剂
    AZ 10417808，caspase-3的选择性非肽抑制剂（Ki = 247 nM）；相对于半胱氨酸蛋白酶1、2、6、7和8（Ki> 10 uM）显示的选择性> 40倍。 了解更多
  34. Ivachtin
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    Ivachtin

    Catalog No. A15300
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    Caspase-3 抑制剂
    Ivachtin是一种有效的，细胞可渗透的，可逆的，非竞争性的Caspase-3抑制剂（IC50 = 23 nM）。 了解更多
  35. Ac-DEVD-CHO
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    Ac-DEVD-CHO

    Catalog No. A15816
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    Caspase 抑制剂
    Ac-DEVD-CHO是醛肽和CPP32/Apopain抑制剂。 了解更多
  36. Z-VEID-FMK
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    Z-VEID-FMK

    Catalog No. A12611
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    Caspase-6 抑制剂
    Z-VEID-FMK是caspase-6 / Mch2的特异性识别序列。 Z-VEID-FMK是不可逆地抑制VEID依赖性胱天蛋白酶（例如caspase-6）活性的合成肽。 抑制剂被设计为甲酯，以促进细胞渗透性。 了解更多
  37. Z-VDVAD-FMK
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    Z-VDVAD-FMK

    Catalog No. A12637
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    Caspase-2 抑制剂
    Z-VDVAD-FMK是caspase-2的细胞渗透性不可逆抑制剂。半胱天冬酶抑制剂在研究生物学过程中起重要作用。 了解更多
  38. Z-DQMD-FMK
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    Z-DQMD-FMK

    Catalog No. A12697
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    Caspase-3 抑制剂
    Z-DQMD-FMK是不可逆地抑制Caspase-3活性的合成肽。 了解更多
  39. Z-IETD-FMK
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    Z-IETD-FMK

    Catalog No. A12800
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    caspase 8 抑制剂
    Z-IETD-FMK是caspase 8的特异性抑制剂。 了解更多
  40. EP1013
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    EP1013

    Catalog No. A11212
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    caspase inhibitor
    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. 了解更多
  41. BOC-D-FMK
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    BOC-D-FMK

    Catalog No. A11356
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    caspase inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. 了解更多
  42. ML132
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    ML132

    Catalog No. A21557
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    caspase 1 inhibitor
    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. 了解更多

产品 251 到 292 共 292个

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