Stat

Inhibitory Selectivity

Catalog No.	Inhibitor Name	STAT3	STAT5	Other
A10817	S3I-201	*
A12733	Stattic	**
A14249	SH-4-54	****	****
A10244	Cryptotanshinone	**
A10396	Fludarabine
A16220	Nifuroxazide
A13474	Napabucasin
A15363	Cucurbitacin I			JAK2
A15364	SD 1008			JAK2
A15366	ZM 449829			JAK3, EGFR, JAK1, CDK4
A15729	Corylifol A	*
A15885	HO-3867
A10087	Artesunate			EXP1(a membrane glutathione S-transferase)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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STAT3-IN-1

Catalog No. A12232
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STAT3 inhibitor

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. 了解更多

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STAT3-IN-3

Catalog No. A18479
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STAT3 inhibitor

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). 了解更多

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AC-4-130

Catalog No. A18314
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STAT5 SH2 domain 抑制剂

AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. 了解更多

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AS-1517499

Catalog No. A16802
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STAT6 抑制剂

AS1517499是一种新型有效的STAT6抑制剂，IC50值为21 nM。了解更多

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C188-9

Catalog No. A16804
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STAT3 抑制剂

C188-9是一种有效的STAT3抑制剂，它以高亲和力（KD = 4.7±0.4 nM）与STAT3结合。C188-9在小鼠中具有良好的耐受性，显示出良好的口服生物利用度，并且集中在肿瘤中。了解更多

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HJC0152

Catalog No. A16806
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STAT3 抑制剂

HJC0152是一种STAT3抑制剂，具有显着改善的水溶性。了解更多

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Napabucasin

Catalog No. A13474
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STAT 抑制剂

Napabucasin是一种口服小分子药物，它可以阻止癌症干细胞（CSC）自我更新，并诱导CSC和非干细胞中的细胞死亡。了解更多

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STAT5 Inhibitor

Catalog No. A13628
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STAT 抑制剂

STAT5抑制剂是一种细胞可渗透的非肽烟酰yl，可通过靶向其SH2结构域（针对STAT5βSH2结构域EPO肽结合活性的IC50 = 47μM）来抑制STAT5。了解更多

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Stattic

Catalog No. A12733
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STAT3 抑制剂

Stattic是第一个非肽类STAT3小分子抑制剂，有效抑制STAT3激活和核易位，IC50为5.1 μM，可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。了解更多

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SH-4-54

Catalog No. A14249
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Stat 抑制剂

SH-4-54是一种有效的STAT抑制剂，对STAT3和STAT5的KD为300 nM和464 nM。了解更多

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HO-3867

Catalog No. A14264
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STAT3 抑制剂

HO-3867是一种选择性STAT3抑制剂。了解更多

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Fludarabine (Fludara)

Catalog No. A10396
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STAT 抑制剂

Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。了解更多

Product Citations (1)

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- Irene Dell'Anno, .et al. Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma, Invest New Drugs, 2020, Dec 9 PMID: 33300108
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Cryptotanshinone

Catalog No. A10244
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Stat3 抑制剂

Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游激酶c的磷酸化。了解更多

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Artesunate

Catalog No. A10087
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cytochrome oxidase 抑制剂

Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫，例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。了解更多

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S3I-201 (NSC 74859)

Catalog No. A10817
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Stat3 抑制剂

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。了解更多

Product Citations (4)

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- Bae WJ, .et al. PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited. J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
- Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
- Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
- Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
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Nitidine chloride

Catalog No. A14701
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STAT 抑制剂

Nitidine chloride是一种天然的苯并菲啶生物碱，已显示出通过诱导细胞凋亡和抑制癌血管生成来抑制癌症的生长。了解更多

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Cucurbitacin I

Catalog No. A15363
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JAK2/STAT3 抑制剂

Cucurbitacin I（Cucumis sativus L.）可以抑制v-Src转化的NIH 3T3细胞中的磷酸酪氨酸Stat3（信号转导和转录激活因子3）水平。了解更多

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SD 1008

Catalog No. A15364
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JAK2/STAT3 抑制剂

SD 1008是JAK2/STAT3信号通路抑制剂，可额外抑制Src。注意到SD 1008可诱导表达组成性活性酪氨酸磷酸化STAT3的细胞系凋亡。了解更多

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ZM 449829

Catalog No. A15366
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JAK/STAT 抑制剂

ZM 449829是有效的、选择性的JAK3抑制剂（Janus酪氨酸激酶3），与JAK3 ATP位点竞争性结合。了解更多

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STA-21

Catalog No. A15885
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STAT-3 抑制剂

STA-21是一种有前途的STAT-3抑制剂，可在类风湿关节炎的实验模型中相互调节Th17和Treg细胞，抑制小鼠和人类的破骨细胞生成并减轻自身免疫炎症。了解更多

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Corylifol A

Catalog No. A15729
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STAT3 抑制剂

Corylifol A是一种从补骨脂中分离出来的酚类化合物。抑制IL-6诱导的STAT3活化和磷酸化（IC50 = 0.8 uM）。了解更多

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Nifuroxazide

Catalog No. A16220
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STAT 抑制剂

Nifuroxazide是STAT激活和信号传导活性的抑制剂，是一种口服硝基呋喃抗生素，用于治疗人类和非人类的结肠炎和腹泻。了解更多

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