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1400W Dihydrochloride是一种缓慢，紧密结合，有效和高度选择性的诱导型一氧化氮合酶抑制剂（Kd = 7 nM）。对nNOS和eNOS具有选择性（Ki值分别为2和50μM）。细胞可渗透并在体内具有活性。
| In vitro | DMSO | 34 mg/mL (135.9 mM) | |
| Water | 34 mg/mL (135.9 mM) | ||
| Ethanol | 34 mg/mL (135.9 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.97 mL | 199.84 mL | 399.68 mL |
| 0.5 mM | 7.99 mL | 39.97 mL | 79.94 mL |
| 1 mM | 4 mL | 19.98 mL | 39.97 mL |
| 5 mM | 0.8 mL | 4 mL | 7.99 mL |
*The above data is based on the productmolecular weight 250.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13583 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 250.2 |
| Formula | C10H15N3 . 2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 214358-33-5 |
| Synonyms | 1400 W |
| SMILES | CC(=NCC1=CC(=CC=C1)CN)N.Cl.Cl |
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