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Autophagy Signaling

产品 1 到 50 共 68个

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  1. ALLO-1
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    ALLO-1

    Catalog No. A18670
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    autophagy receptor
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. 了解更多
  2. IITZ-01
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    IITZ-01

    Catalog No. A20192
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    Lysosomotropic autophagy inhibitor
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. 了解更多
  3. EACC
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    EACC

    Catalog No. A19062
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    Autophagy inhibitor
    EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. 了解更多
  4. SMER28
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    SMER28

    Catalog No. A15867
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    Autophagy Activator
    SMER28是自噬的小分子增强剂（SMER），在哺乳动物细胞中独立于雷帕霉素诱导自噬。 了解更多
  5. Aumitin
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    Aumitin

    Catalog No. A18838
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    Autophagy inhibitor
    Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. 了解更多
  6. EN6
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    EN6

    Catalog No. A18524
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    Autophagy activator
    EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. 了解更多
  7. PIK-III
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    PIK-III

    Catalog No. A15868
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    Autophagy 抑制剂
    PIK-III是βVPS34酶活性的选择性抑制剂。 了解更多
  8. QX77
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    QX77

    Catalog No. A13379
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    autophagy (CMA) activator
    QX77 is a chaperone-mediated autophagy (CMA) activator. 了解更多
  9. Autophinib
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    • 最新产品

    Autophinib

    Catalog No. A17241
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    Autophagy inhibitor
    Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. 了解更多
  10. 3-Methyladenine
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    3-Methyladenine

    Catalog No. A11151
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    Autophagy/PI3K 抑制剂
    3-Methyladenine是III类磷脂酰肌醇3-激酶（PI 3-激酶）的抑制剂。 了解更多
  11. Monensin sodium
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    Monensin sodium

    Catalog No. A10603
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    ionophore
    Monensin sodium是一种离子载体，是自噬在牲畜饲料中的抑制剂。它抑制自噬，干扰自噬体和溶酶体的融合。 了解更多
  12. Lys01 trihydrochloride
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    Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. 了解更多
  13. ROC-325
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    ROC-325

    Catalog No. A17031
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    Autophagy 抑制剂
    ROC-325是自噬抑制剂。与现有的自噬抑制剂羟氯喹（HCQ）相比，ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。 了解更多
  14. Hydroxychloroquine Sulfate
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    Hydroxychloroquine Sulfate

    Catalog No. A14208
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    Hydroxychloroquine Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿性关节炎和其他自身免疫性，炎性和皮肤病性疾病。还可以作为自噬和通行费样受体（TLR）7/9的抑制剂。 了解更多
  15. Spautin-1
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    Spautin-1

    Catalog No. A12942
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    Autophagy 抑制剂
    Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。 了解更多
  16. Resveratrol
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    Resveratrol

    Catalog No. A10785
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    Resveratrol具有广泛的靶标，包括环氧合酶（COX，IC50 = 1.1μM），脂氧合酶（LOX，IC50 = 2.7μM），激酶，sirtuins和其他蛋白质。它具有抗癌，抗炎，降低血糖和其他有益的心血管作用。 了解更多
  17. SBC-115076
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    SBC-115076

    Catalog No. A15769
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    PCSK9 拮抗剂
    SBC-115076是抗蛋白原转化酶枯草杆菌蛋白酶kexin 9型（抗PCSK9）化合物，用于治疗和/或预防心血管疾病。 了解更多
  18. SBI-0206965
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    SBI-0206965

    Catalog No. A15795
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    ULK1 抑制剂
    SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。 了解更多
  19. MRT68921
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    MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 抑制剂
    MRT68921是一种有效的双重自噬激酶ULK1/2抑制剂，IC50分别为2.9 nM和1.1 nM。 了解更多
  20. STF-62247
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    STF-62247

    Catalog No. A10866
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    Autophagy Inducer
    STF-62247是一种小分子激动剂，可诱导已经失去von Hippel-Lindau（VHL）肿瘤抑制活性（IC50 = 625 nM）的肾细胞癌（RCC）细胞致死，并自噬。 了解更多
  21. Flubendazole (Flutelmium)
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    Flubendazole (Flutelmium)

    Catalog No. A11656
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    autophagy inducer
    Flubendazole (Flutelmium)是一种驱虫药，用于保护犬猫体内的寄生虫和蠕虫。 了解更多
  22. Scutellarein
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    Scutellarein

    Catalog No. A12234
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    Scutellarein是从灯盏细辛中提取的主要活性成分。 了解更多
  23. Lys05
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    Lys05

    Catalog No. A16358
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    Autophagy 抑制剂
    Lys05是有效的溶酶体自噬抑制剂。Lys05是一种先前未描述的二聚氯喹，与HCQ相比，它更有效地积聚在溶酶体中并阻止自噬。 了解更多
  24. Azithromycin Dihydrate
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    Azithromycin Dihydrate

    Catalog No. A16421
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    Azithromycin Dihydrate是一种酸稳定的口服大环内酯类抗菌药物，在结构上与红霉素有关。 了解更多
  25. Chloroquine Phosphate
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    Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine Phosphate是一种4-氨基喹啉抗疟和抗类风湿药，也可作为ATM活化剂。 了解更多
  26. CZC54252 hydrochloride
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    CZC54252 hydrochloride

    Catalog No. A15510
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    LRRK2 抑制剂
    CZC54252 hydrochloride是一种有效的LRRK2抑制剂，野生型和G2019S LRRK2的IC50分别为1.28 nM和1.85 nM。 了解更多
  27. PF-06447475
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    PF-06447475

    Catalog No. A15504
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    LRRK2 抑制剂
    PF-06447475是一种高效，选择性，脑渗透性LRRK2抑制剂，对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。 了解更多
  28. LRRK2-IN-1
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    LRRK2-IN-1

    Catalog No. A11477
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    LRRK2 抑制剂
    LRRK2-IN-1抑制G2019S突变体和野生型LRRK2激酶活性，IC50值分别为6和13 nM。 了解更多
  29. TAE684
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    TAE684

    Catalog No. A10662
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    ALK 抑制剂
    TAE684是ALK的抑制剂，也是LRRK2激酶活性的有效抑制剂（针对野生型LRRK2的IC（50）为7.8nM，针对G2019S突变体的为6.1nM）。 了解更多
  30. CZC-25146 hydrochloride
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    CZC-25146 hydrochloride

    Catalog No. A13448
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    LRRK2 抑制剂
    CZC-25146是一种高效、选择性的LRRK2抑制剂。CZC-25146可防止突变LRRK2对培养的啮齿动物和人神经元的损伤。 了解更多
  31. GNE-7915
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    GNE-7915

    Catalog No. A13748
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    LRRK2 抑制剂
    GNE-7915是一种富含亮氨酸重复激酶2（LRRK2）的血脑屏障（BBB）渗透性小分子抑制剂。 了解更多
  32. CZC-25146
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    • 最新产品

    CZC-25146

    Catalog No. A17125
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    LRRK2 抑制剂
    CZC-25146是有效的LRRK2抑制剂。 了解更多
  33. GNE 9605
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    GNE 9605

    Catalog No. A14149
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    LRRK2 抑制剂
    GNE-9605是一种高效且选择性强的富含亮氨酸的重复激酶2（LRRK2）抑制剂，Ki和IC50分别为2 nM和19 nM。 了解更多
  34. JH-II-127
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    JH-II-127

    Catalog No. A15777
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    LRRK2 抑制剂
    JH-II-127是一种高效，选择性和脑渗透性的LRRK2抑制剂，对于LRRK2野生型，LRRK2-G2019S和LRRK2-A2016T，IC50为6.6 nM，2.2 nM和47.7 nM。 了解更多
  35. GNE0877
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    GNE0877

    Catalog No. A13969
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    LRRK2 抑制剂
    GNE-0877是一种高效且选择性的LRRK2抑制剂。 了解更多
  36. HG-10-102-01
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    HG-10-102-01

    Catalog No. A12919
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    LRRK2 抑制剂 III
    HG-10-102-01是野生型LRRK2的脑渗透剂，有效抑制剂。 了解更多
  37. PFE-360 (PF-06685360)
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    PFE-360 (PF-06685360)

    Catalog No. A18816
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    LRRK2 inhibitor
    PFE-360, also known asd PF-06685360, is a potent and selective inhibitor of LRRK2 kinase. 了解更多
  38. GSK2578215A
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    GSK2578215A

    Catalog No. A12798
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    LRRK2 kinase 抑制剂
    GSK2578215A是一种有效的富含亮氨酸的重复激酶2（LRRK2）抑制剂（LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM）。 了解更多
  39. PF-06371900
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    • 最新产品

    PF-06371900

    Catalog No. A17221
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    LRRK2 inhibitor
    PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. 了解更多
  40. AMG 487 S-enantiomer
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    AMG 487 S-enantiomer

    Catalog No. A21874
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    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多
  41. SCH 546738
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    SCH 546738

    Catalog No. A21554
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    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多
  42. AMG 487
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    AMG 487

    Catalog No. A21162
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    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多
  43. Kynurenic acid sodium
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    Kynurenic acid sodium

    Catalog No. A20000
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    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多
  44. GPR35 agonist 1
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    GPR35 agonist 1

    Catalog No. A12462
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    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多
  45. CXCR2-IN-1
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    CXCR2-IN-1

    Catalog No. A12649
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    CXCR2 激动剂
    CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. 了解更多
  46. USL311
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    USL311

    Catalog No. A18778
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    CXCR4 拮抗剂
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. 了解更多
  47. PS372424
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    PS372424

    Catalog No. A19421
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    Human CXCR3 拮抗剂
    PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. 了解更多
  48. Kynurenic acid
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    Kynurenic acid

    Catalog No. A16581
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    GPR35/CXCR8 拮抗剂
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. 了解更多
  49. Plerixafor 8HCl (DB06809)
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    Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 拮抗剂
    Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导调节的趋化性， IC50分别为44 nM和5.7 nM。 了解更多
  50. AMD 070
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    AMD 070

    Catalog No. A11315
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    CXCR4 拮抗剂
    AMD 070是CXCR4趋化因子受体拮抗剂。 了解更多

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分类
  1. Autophagy (25)
  2. LRRK2 (14)
  3. CXCR (29)
作用机制
  1. Inhibitor (抑制剂) (30)
  2. Agonist (激动剂) (5)
  3. Antagonist (拮抗剂) (19)
  4. Activator (激活剂) (5)
  5. Modulator (调节剂) (1)
  6. Inducer (诱导剂) (2)
靶点
  1. Autophagy (1)
  2. CXCL12 (1)
  3. CXCL8 (2)
  4. CXCR1 (4)
  5. CXCR2 (9)
  6. CXCR4 (11)
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