你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
MAPK

MAPK

Quick View
GSK1120212 (JTP-74057, Trametinib)

Catalog No. A11029
Quick View

添加到收藏
MEK 抑制剂

GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性，而不是其他98种激酶的活性。了解更多

Product Citations (10)

Bulk Inquiry Free Sample
- Nao Yamagishi, .et al. Non-canonical Regulation of EGFR by the Air Pollutant 9,10-Phenanthrenequinone, Biol Pharm Bull, 2022, 45(10):1553-1558 PMID: 36184515
- Hayato Mizuta, .et al. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
- Keisuke Yanagida, .et al. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization, Dev Cell, 2020, 52 (6), 779-793 PMID: 32059774
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Kanemaru Y, .et al. Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy, Acta Neuropathol Commun, 2019, Jul 25;7(1):119 PMID: 31345255
- Chul Min Park, .et al. Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways, Oncol Lett, 2018, Feb; 15(2): 1758-1762 PMID: 29434871
- Sumi T, .et al. Trametinib downregulates survivin expression in RB1-positive KRAS-mutant lung adenocarcinoma cells, Biochem Biophys Res Commun, 2018, Jun 18;501(1):253-258 PMID: 29727601
- Toshiyuki Sumi, .et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Yuki Kawasaki, .et al. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain, Sci Rep, 2016, 6: 31502 PMID: 27531070
Quick View
PD98059

Catalog No. A10705
Quick View

添加到收藏
MEK 抑制剂

PD98059是一种非ATP竞争性的MEK抑制剂，无细胞试验中IC50为2 μM，特异性抑制MEK-1介导的MAPK激活；不直接抑制ERK1或ERK2。了解更多

Product Citations (9)

Bulk Inquiry
- Anna Nakanishi, .et al. Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice, Regen Ther, 2022, Sep 9;21:351-361 PMID: 36161099
- Isamu Ogawa, .et al. Suspension culture of human induced pluripotent stem cell-derived intestinal organoids using natural polysaccharides, Biomaterials, 2022, Sep;288:121696 PMID: 36038421
- Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
- Akinobu Nakamura, .et al. Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells, ACS Chem Biol, 2020, Apr 17;15(4):1004-1015 PMID: 32162909
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Kwang Woon Kim, .et al. Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma, Oncotarget, 2019, Sep 24; 10(54): 5645-5659 PMID: 31608140
- Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
- Kim MH, .et al. C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation, Oncol Rep, 2018, Nov;40(5):2977-2987 PMID: 30226616
- Onozato D, .et al. Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions, Stem Cells Dev, 2018, Aug 1;27(15):1033-1045 PMID: 29742964
Quick View
AZD6244 (Selumetinib)

Catalog No. A10257
Quick View

添加到收藏
MEK 抑制剂

Selumetinib (AZD6244)是一种有效，高选择性的MEK抑制剂，ARRY142886，AZD-6244和ARRY-142886是MEK 1/2抑制剂，GI50值在14至50 nm之间。了解更多

Product Citations (1)

Bulk Inquiry
- Chia-Chi Chang, .et al. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057
Quick View
MEK162 (ARRY-438162, Binimetinib)

Catalog No. A11493
Quick View

添加到收藏
MEK1/2 抑制剂

MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- S Shahab, .et al. MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors, J Neuropathol Exp Neurol, 2020, Jul 1;79(7):746-753
- Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
- Alquezar C, .et al. Increasing progranulin levels and blockade of the ERK1/2 pathway: Upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia, Eur Neuropsychopharmacol, 2015, Mar;25(3):386-403 PMID: 25624003
Quick View
U0126-EtOH

Catalog No. A10957
Quick View

添加到收藏
MEK 抑制剂

U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
- Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
Quick View
PD0325901

Catalog No. A10256
Quick View

添加到收藏
MEK 抑制剂

PD0325901是一种选择性的，非ATP竞争性MEK抑制剂，无细胞试验中IC50为0.33 nM，对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- Jan Langkabel, .et al. Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs, bioRxiv, 2021, January 25
- Ryan Clarke, .et al. Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities, Mol Cell, 2021, Jan 21;81(2):226-238.e5 PMID: 33378644
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Fukumoto S, .et al. Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27, Acta Histochem, 2018, Feb;120(2):142-150 PMID: 29397960
- Yoshiteru Yano, .et al. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells, Regenerative Therapy, 2016, 3 (2016) 1-6
Quick View
BIX 02189

Catalog No. A10151
Quick View

添加到收藏
MEK 抑制剂

BIX 02189是选择性双重MEK5和ERK5（或BMK1）激酶抑制剂，对于MEK5，ERK5，TGFbR1和其他紧密相关的激酶，IC50值分别为1.5、59、580和> 6200 nM。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738
Quick View
GDC-0973 (Cobimetinib)

Catalog No. A11441
Quick View

添加到收藏
MEK1 抑制剂

GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂，IC50为4.2 nM，对MEK1的选择性选择性是对MEK2的100倍以上，并且当针对一组超过100个丝氨酸的抑制剂进行测试时，没有显示出明显的抑制作用。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Yunping Hu, .et al. FGFR1/MAPK-directed brachyury activation drives PD-L1-mediated immune evasion to promote lung cancer progression, Cancer Lett, 2022, Oct 28;547:215867 PMID: 35985510
- Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
Quick View
Refametinib (RDEA-119, BAY 86-9766)

Catalog No. A12866
Quick View

添加到收藏
MEK1/2 抑制剂

Refametinib (RDEA-119,BAY 86-9766)是一种口服生物利用型选择性MEK抑制剂，EC50为 2.0-15 nM。具有潜在的抗肿瘤活性。了解更多

Product Citations (1)

Bulk Inquiry
- Estelle Daudigeos-Dubus, etc. Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models. PLoS One. 2015; 10(11): e0142612.
Quick View
Cobimetinib (racemate)

Catalog No. A15050
添加到收藏
MEK 抑制剂

Cobimetinib (racemate)是一种有效的，高度选择性的MEK1/2抑制剂。了解更多

Product Citations (2)

Bulk Inquiry
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
- Chun-Yu Liu, .et al. Varlitinib Downregulates HER/ERK Signaling and Induces Apoptosis in Triple Negative Breast Cancer Cells, Cancers (Basel), 2019, Jan 17;11(1) PMID: 30658422
Quick View
BI-847325

Catalog No. A15762
Quick View

添加到收藏
MEK/Aurora 抑制剂

BI-847325是一种生物利用型选择性MEK/Aurora双重激酶抑制剂，对于非洲爪蟾Aurora B，人Aurora A和Aurora C以及IC50分别为3 nM，25 nM，15 nM，25 nM和4 nM IC50人MEK1和MEK2。了解更多

Product Citations (2)

Bulk Inquiry
- Hilda Samimi, .et al. Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma, Thyroid Res, 2021, Dec 3;14(1):27 PMID: 34861882
- Hilda Samimi, .et al. Transcript-level regulation of MALAT1-mediated cell cycle and apoptosis genes using dual MEK/Aurora kinase inhibitor "BI-847325" on anaplastic thyroid carcinoma, DARU J Pharm Sci, 2019, 1-7 PMID: 31077090
Quick View
Honokiol

Catalog No. A10453
Quick View

添加到收藏
Antiangiogenic and Antitumor Agent

Honokiol是存在于广玉兰的球果、树皮和叶子中的木脂素，在黑色素瘤、肉瘤、骨髓瘤、白血病、膀胱、肺、前列腺、口腔鳞状细胞癌和结肠癌细胞系中显示促凋亡作用。了解更多

Bulk Inquiry Free Sample
Quick View
SL-327

Catalog No. A14137
Quick View

添加到收藏
MKK/MEK 抑制剂

SL-327是MEK1和MEK2的选择性抑制剂（IC50值分别为0.18和0.22μM）；在体外阻断海马LTP。全身性给药后，体内的脑渗透剂会阻止大鼠的恐惧条件和学习，并在小鼠中产生神经保护作用。了解更多

Bulk Inquiry Free Sample
Quick View
Refametinib

Catalog No. A11264
Quick View

添加到收藏
MEK 抑制剂

Refametinib是一种有效的，ATP非竞争性和高度选择性的MEK1和MEK2抑制剂，IC50分别为19 nM和47 nM。了解更多

Bulk Inquiry
Quick View
Cobimetinib (R-enantiomer)

Catalog No. A15051
Quick View

添加到收藏
MEK 抑制剂

Cobimetinib R-enantiomer是Cobimetinib的R对映异构体，Cobimetinib是一种有力的，高选择性的促分裂原活化蛋白激酶（MEK1/2）抑制剂。了解更多

Bulk Inquiry
Quick View
MEK inhibitor

Catalog No. A15157
Quick View

添加到收藏
MEK 抑制剂

MEK inhibitor是一种有效的MEK抑制剂，抗肿瘤剂。了解更多

Bulk Inquiry
Quick View
G-479

Catalog No. A14380
Quick View

添加到收藏
MEK 抑制剂

G-479是有效的MEK抑制剂。在许多方面，极性分布在整个分子中的G-479被证明具有比GDC-0623更高的生物活性。了解更多

Bulk Inquiry
Quick View
GDC-0623

Catalog No. A12974
Quick View

添加到收藏
MEK1 抑制剂

GDC-0623是一种有效的ATP竞争性MEK1抑制剂，Ki为0.13 nM。了解更多

Bulk Inquiry
Quick View
PD 198306

Catalog No. A16032
Quick View

添加到收藏
MEK 抑制剂

PD 198306是一种有效的，选择性的和非ATP竞争性MAPK/ERK激酶（MEK）抑制剂。了解更多

Bulk Inquiry
Quick View
PD 334581

Catalog No. A16044
Quick View

添加到收藏
MEK1 抑制剂

PD 334581在生物学研究中用于评估卤素键合，作为合理药物设计的新型相互作用。它也是MEK1的抑制剂。了解更多

Bulk Inquiry
Quick View
GW284543

Catalog No. A18808
Quick View

添加到收藏
MEK5 inhibitor

GW284543, also known as UNC10225170;, is a potent and selective MEK5 inhibitor with the potential for cancer treatment. 了解更多

Bulk Inquiry
Quick View
EBI-1051

Catalog No. A13176
Quick View

添加到收藏
MEK inhibitor

EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM. 了解更多

Bulk Inquiry
Quick View
Cobimetinib hemifumarate

Catalog No. A18033
Quick View

添加到收藏
MEK1 inhibitor

Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. 了解更多

Bulk Inquiry
Quick View
Trametinib (DMSO solvate)

Catalog No. A21450
Quick View

添加到收藏
MEK inhibitor

Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM. 了解更多

Product Citations (1)

Bulk Inquiry
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Quick View
BIX02189

Catalog No. A21729
Quick View

添加到收藏
MEK5 inhibitor

BIX02189 is a potent and selective MEK5 inhibitor with an IC50 of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC50 of 59 nM. 了解更多

Bulk Inquiry
Quick View
PD184352 (CI-1040)

Catalog No. A10212
Quick View

添加到收藏
MEK1/2 抑制剂

PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂，在基于细胞的测定中，IC50为17 nM，对MEK1/2的选择性是对MEK5的100倍。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Sachio Suzuki, .et al. A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation, Cell Chem Biol, 2022, Sep 15;29(9):1446-1464 PMID: 35835118
- Masaru Yoshikawa, .et al. Synthetic Protein Condensates That Inducibly Recruit and Release Protein Activity in Living Cells, J Am Chem Soc, 2021, May 5;143(17):6434-6446 PMID: 33890764
Quick View
AS703026 (Pimasertib)

Catalog No. A10089
Quick View

添加到收藏
MEK1/2 抑制剂

AS703026 (Pimasertib)是一种新型的，选择性的，口服可生物利用的MEK1/2抑制剂，可抑制MM细胞的生长和存活以及细胞因子诱导的破骨细胞分化。了解更多

Bulk Inquiry
Quick View
TAK-733

Catalog No. A11040
Quick View

添加到收藏
MEK 抑制剂

TAK-733是一种有效的，选择性的MEK变构抑制剂，作用于MEK1，IC50为3.2 nM，抑制Abl1，AKT3，c-RAF，CamK1，CDK2及c-Met等活性。了解更多

Bulk Inquiry Free Sample
Quick View
AZD8330

Catalog No. A10115
Quick View

添加到收藏
MEK 抑制剂

AZD8330是新型，选择性，非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。阶段1。了解更多

Bulk Inquiry
Quick View
PD318088

Catalog No. A10704
Quick View

添加到收藏
MEK 抑制剂

PD318088是MEK1和MEK2的抑制剂。了解更多

Bulk Inquiry
Quick View
BIX02188

Catalog No. A10150
Quick View

添加到收藏
MEK5 抑制剂

BIX02188是一种有效的选择性MEK5抑制剂。了解更多

Bulk Inquiry
Quick View
RO4927350

Catalog No. A11247
Quick View

添加到收藏
MEK1/2 抑制剂

RO4927350是一种有效且高度选择性的非ATP竞争性MEK1/2抑制剂。了解更多

Bulk Inquiry
Quick View
Balamapimod (MKI-833)

Catalog No. A13119
Quick View

添加到收藏
Ras/Raf/MEK 抑制剂

Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。了解更多

Bulk Inquiry
Quick View
RO5126766 (CH5126766)

Catalog No. A14019
Quick View

添加到收藏
Raf/MEK dual 抑制剂

RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶（MAPK）具有特异性的蛋白激酶抑制剂，具有潜在的抗肿瘤活性。了解更多

Product Citations (1)

Bulk Inquiry
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Quick View
Hypothemycin

Catalog No. A13750
Quick View

添加到收藏
Hypothemycin是间苯二酸内酯聚酮。已发现抑制用抗CD3 mAb+ PMA刺激的小鼠和人T细胞以及仅用抗CD3 mAb刺激的人PBMC的增殖。了解更多

Bulk Inquiry
Quick View
RO4987655

Catalog No. A13272
Quick View

添加到收藏
MEK1 抑制剂

RO4987655是一种口服活性小分子，靶向有丝分裂原激活的蛋白激酶激酶1（MAP2K1或MEK1），抑制 MEK1/MEK2，IC50 为 5.2 nM。具有潜在的抗肿瘤活性。了解更多

Bulk Inquiry
Quick View
SCH772984

Catalog No. A12824
Quick View

添加到收藏
ERK 抑制剂

SCH772984是一种新型的ERK1/2特异性抑制剂，IC50分别为4 nM和1 nM。了解更多

Product Citations (6)

Bulk Inquiry Free Sample
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
- Yajun Li, .et al. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-??B pathway, Cell Prolif, 2022, Oct;55(10) PMID: 35708050
- Sergey A. Dyshlovoy, .et al. Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells, Pharmaceuticals, 2021, 14(10), 949
- Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
- Guo X, .et al. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus, Pflugers Arch, 2018, Jun;470(6):909-921 PMID: 29441404
- Takuya Hasegawa, .et al. ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer, FEBS Open Bio, 2017, Aug; 7(8): 1154-1165 PMID: 28781955
Quick View
FR 180204

Catalog No. A14119
Quick View

添加到收藏
ERK 抑制剂

FR 180204是细胞外信号调节激酶（ERK）的新型选择性抑制剂，它可能是类风湿关节炎的潜在新疗法。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
- Dyshlovoy SA, .et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin, Proteomics, 2017, Jun;17(11) PMID: 28445005
Quick View
TCS ERK 11e (VX-11e)

Catalog No. A12505
Quick View

添加到收藏
ERK2 抑制剂

TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2（ERK2）抑制剂（ERK2，GSK-3，Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM）。有效阻断HT29细胞的增殖（IC50 = 48 nM）。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Qi-sang Guo, etc. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Sci Rep. 2017; 7: 2117.
Quick View
ERK5-IN-2

Catalog No. A18871
Quick View

添加到收藏
ERK5 inhibitor

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. 了解更多

Bulk Inquiry
Quick View
BAY885

Catalog No. A13765
Quick View

添加到收藏
ERK5 inhibitor

BAY885 is a novel ERK5 inhibitor. 了解更多

Bulk Inquiry
Quick View
Pluripotin (SC-1)

Catalog No. A11225
Quick View

添加到收藏
ERK1/RasGAP 抑制剂

Pluripotin (SC-1)的活性是通过联合抑制RasGAP和ERK1介导的，其Kd值分别为98和212 nM。了解更多

Product Citations (1)

Bulk Inquiry
- Mohammad Azhar, .et al. Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML, Blood Adv, 2022, Aug 31 PMID: 36044389
Quick View
Ulixertinib (BVD-523, VRT752271)

Catalog No. A11794
Quick View

添加到收藏
ERK1/ERK2 抑制剂

Ulixertinib (BVD-523,VRT752271)是ERK蛋白激酶的吡咯抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Quick View
GDC0994 (Ravoxertinib)

Catalog No. A13420
Quick View

添加到收藏
ERK1/2 抑制剂

GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。了解更多

Bulk Inquiry Free Sample
Quick View
XMD 17-109

Catalog No. A14090
Quick View

添加到收藏
ERK5 抑制剂

XMD17-109是一种新型的ERK-5特异性抑制剂，在HEK293细胞中的EC50值为4.2 uM。了解更多

Bulk Inquiry
Quick View
XMD8-92

Catalog No. A11609
Quick View

添加到收藏
BMK1/ERK5 抑制剂

XMD8-92是一种有效的选择性BMK1/ERK5抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
TMCB

Catalog No. A13977
Quick View

添加到收藏
CK2/ERK8 抑制剂

MCB抑制酪蛋白激酶2（CK2）和细胞外信号调节激酶8（ERK8/MAPK15）（CK2和ERK8的IC50 = 0.50 uM）。了解更多

Bulk Inquiry
Quick View
DEL-22379

Catalog No. A15802
Quick View

添加到收藏
ERK 抑制剂

DEL-22379是一种有效的选择性ERK二聚体抑制剂，可抑制ERK二聚体而不影响ERK磷酸化，阻止由RAS-ERK途径癌基因驱动的肿瘤发生。了解更多

Bulk Inquiry Free Sample
Quick View
APS-2-79

Catalog No. A16231
Quick View

添加到收藏
KSR/Ras 抑制剂

APS-2-79是RAF通过直接结合KSR活性位点而使MEK磷酸化的拮抗剂。了解更多

Bulk Inquiry
Quick View
ERK5-IN-1

Catalog No. A16232
Quick View

添加到收藏
ERK5 抑制剂

ERK5-IN-1表现出对ERK5的有效抑制，其细胞EC50值为0.19 uM，酶促IC50值为0.087 uM，LRRK2 [G2019S]具有酶促IC50值为0.026uM。了解更多

Bulk Inquiry

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.