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￥ 0.00 Endocrinology / Hormones
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Tamoxifen Citrate
Catalog No. A10885 Estrogen receptor 拮抗剂Tamoxifen Citrate是哺乳动物甾醇异构酶的选择性和有效抑制剂。 了解更多 -
Elacestrant
Catalog No. A12244 Estrogen receptor degraderElacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. 了解更多 -
GDC-0927 Racemate
Catalog No. A21507 estrogen receptor degraderGDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. 了解更多 -
Fulvestrant R enantiomer
Catalog No. A21545 estrogen receptor antagonistFulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. 了解更多 -
Pipendoxifene hydrochloride
Catalog No. A21623 estrogen receptor modulatorsPipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs). 了解更多 -
H3B-6545 Hydrochloride
Catalog No. A21629 estrogen receptor covalent antagonistH3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多 -
AZD9496 maleate
Catalog No. A21726 estrogen receptor (ERα) antagonistAZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). 了解更多 -
Enclomiphene citrate
Catalog No. A21830 oestrogen receptor antagonistEnclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. 了解更多 -
4-Hydroxytamoxifen
Catalog No. A20955 estrogen receptor modulator4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). 了解更多 -
Fulvestrant (Faslodex)
Catalog No. A10410 Aromatase 抑制剂Fulvestrant是一种雌激素受体拮抗剂，没有激动剂作用，它通过下调和降解雌激素受体发挥作用。 了解更多 -
Kaempferol
Catalog No. A10495 ERRα and ERRγ inverse 激动剂Kaempferol被发现抑制Ki为0.3-0.5 μM的牛主动脉肌球蛋白轻链激酶，并且还被发现通过新的ERK-NFκB-cMyc-p21途径抑制VEGF表达和体外血管生成。 了解更多 -
Evista (Raloxifene HCl)
Catalog No. A10375 Evista (Raloxifene HCl)是一种口服选择性雌激素受体调节剂（SERM），对骨骼具有雌激素作用，对子宫和乳房具有抗雌激素作用。 了解更多 -
GSK1292263
Catalog No. A10439 -
Mifepristone (Mifeprex)
Catalog No. A10591 Mifepristone (Mifeprex)是一种抗氧化剂和糖皮质激素受体拮抗剂，具有抑制NFκB活化的能力，NFκB是一种影响各种粘附分子和几种炎症基因表达的核转录因子。 了解更多 -
Acolbifene (EM 652, SCH57068)
Catalog No. A12771 estrogen receptor modulatorAcolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂，LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合，阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂（SERM）的一种。 了解更多 -
Zearalenone
Catalog No. A13740 Zearalenone是通常由镰刀菌属物种产生的一种植物雌激素真菌毒素，被证明是一种细胞毒性化合物，但芦荟结合雌激素受体（ER）（ERβ和ERα的IC50值分别为166和240 nM），并被发现可以刺激转录。两种亚型的活性在1-10 nM之间。 了解更多 -
Arzoxifene HCl
Catalog No. A13292 Arzoxifene HCl是Arzoxifene的盐酸盐，Arzoxifene是具有抗雌激素特性的合成芳族衍生物。Arzoxifene作为混合的雌激素激动剂/拮抗剂与雌激素受体结合。 了解更多 -
Ospemifene
Catalog No. A14261 -
DY131
Catalog No. A15071 -
Toremifene
Catalog No. A15265 -
AZD9496
Catalog No. A15822 -
(E/Z)-4-hydroxy Tamoxifen
Catalog No. A12532 Estrogen receptor 拮抗剂(E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物，是一种选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。 了解更多 -
RAD1901 HCl salt
Catalog No. A15990 SERD/SERMRAD1901 HCl salt是口服的选择性雌激素受体降解剂（SERD）和选择性雌激素受体调节剂（SERM），具有潜在的抗肿瘤活性和类似雌激素的活性。 了解更多 -
GDC-0810 (Brilanestrant)
Catalog No. A15958 Estrogen receptor degraderGDC-0810 (Brilanestrant)是一种口服可生物利用的选择性雌激素受体降解剂（SERD），在耐他莫昔芬的乳腺癌异种移植物中表现出强大的活性。 了解更多 -
Endoxifen E-isomer hydrochloride
Catalog No. A16343 Endoxifen E-isomer hydrochloride是他莫昔芬的代谢产物和有效的选择性雌激素反应调节剂（SERM）。 了解更多 -
Lasofoxifene Tartrate
Catalog No. A18097 selective Estrogen receptor modulatorLasofoxifene tartrate is a third-generation selective estrogen receptor modulator. 了解更多 -
PROTAC ERRα ligand 2
Catalog No. A18939 ERRα inverse agonistPROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多 -
PROTAC ERRα Degrader-1
Catalog No. A18910 ERRα DegraderPROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多 -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多 -
Asoprisnil
Catalog No. A19030 Progesterone receptor modulatorAsoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. 了解更多
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- Estrogen Receptors (49)
- Progesterone Receptors (16)
- Androgen Receptors (20)
- GPR (18)
- 5-alpha-reductase (5)
- Pregnane X Receptors (4)
- renin-angiotensin-aldosterone system (RAAS) (61)
- Aromatase (8)
- Glucocorticoid receptors (26)
- Vitamin D Receptors (1)
- GnRH receptor (19)
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- 作用机制
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- Inhibitor (抑制剂) (42)
- Agonist (激动剂) (59)
- Antagonist (拮抗剂) (53)
- Activator (激活剂) (1)
- Modulator (调节剂) (19)
- Blocker (阻断剂) (1)
- Degrader (降解剂) (6)
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- Aromatase (4)
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