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2-Methoxyestradiol是一种凋亡，抗增殖和抗血管生成剂。通过两种途径诱导p53诱导的细胞凋亡：p38和NF-κB的激活；和激活JNK和AP-1导致Bcl-2磷酸化。
靶点信息
| HIF-2α (Rat aortic smooth muscle A-10 cells) | Microtubule Associated (Cell-free assay) | HIF-1α (MDA-MB-231 cells) | ||
| In vitro (25°C) | DMSO | 55 mg/mL (181.87 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2%DMSO+30%PEG300+5%Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.07 mL | 165.34 mL | 330.69 mL |
| 0.5 mM | 6.61 mL | 33.07 mL | 66.14 mL |
| 1 mM | 3.31 mL | 16.53 mL | 33.07 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.61 mL |
*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10012 |
|---|---|
| M. Wt | 302.4 |
| Formula | C19H26O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 362-07-2 |
| Synonyms | 2-ME2 |
| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3 |
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