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Domatinostat (4SC-202)

Domatinostat (4SC-202)

Name: Domatinostat (4SC-202)
SKU: A14354

目录号: A14354

HDAC 抑制剂

Domatinostat (4SC-202) Chemical Structure

CAS NO. 910462-43-0

4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶（HDACs）同工酶1、2和3的抑制剂，具有潜在的抗肿瘤活性。

库存：现货

规格	价格	数量
10 mg	￥ 1,050.00
25 mg	￥ 2,100.00
50 mg	￥ 3,150.00
10mM * 1mL in DMSO	￥ 882.00

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产品详情

生物活性

4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶（HDACs）同工酶1、2和3的抑制剂，具有潜在的抗肿瘤活性。

靶点信息

HDAC3	HDAC2	HDAC1
0.57 μM	1.12 μM	1.20 μM

溶解度 *

In vitro (25°C)	DMSO	77 mg/mL (172.06 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.35 mL	111.73 mL	223.46 mL
0.5 mM	4.47 mL	22.35 mL	44.69 mL
1 mM	2.23 mL	11.17 mL	22.35 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14354
作用机制	Inhibitor (抑制剂)
M. Wt	447.51
Formula	C23H21N5O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	910462-43-0
Synonyms	0
SMILES	CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N