5-HT Receptors

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  1. LY 344864

    Catalog No. A15148
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    5HT1F 激动剂
    LY344864是一种选择性受体激动剂,对最近克隆的5-HT1F受体的亲和力为6 nM(Ki)。 了解更多
  2. Pimavanserin (ACP-103)

    Catalog No. A14434
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    5-HT2A receptor 激动剂
    Pimavanserin (ACP-103)是一种有效的选择性5-HT2A受体反向激动剂,在基于细胞的功能测定中,平均pIC50为8.7。 了解更多
  3. WAY 181187

    Catalog No. A14163
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    5-HT6 激动剂
    WAY 181187是一种高亲和力且选择性的5-HT6激动剂,Ki值为2.2 nM。 了解更多
  4. CP-809101

    Catalog No. A12481
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    5-HT2C receptor agonist
    CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. 了解更多
  5. Donitriptan

    Catalog No. A13145
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    5-HT1B/1D receptors agonist
    Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. 了解更多
  6. YM348

    Catalog No. A12290
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    5-HT2C receptor agonist
    YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). 了解更多
  7. AP521

    Catalog No. A12280
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    human 5-HT1A receptor agonist
    AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. 了解更多
  8. PRX933 hydrochloride

    Catalog No. A12261
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    5-HT2c receptor agonist
    PRX933 hydrochloride is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1. 了解更多
  9. Lesopitron dihydrochloride

    Catalog No. A12950
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    5-HT1A receptor agonist
    Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. 了解更多
  10. RU 24969

    Catalog No. A20857
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    5-HT1A/5-HT1B receptors agonist
    RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors. 了解更多
  11. Befiradol

    Catalog No. A21189
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    5-HT1A receptor agonist
    Befiradol (NLX-112) is a selective 5-HT1A receptor agonist. 了解更多
  12. WAY 163909

    Catalog No. A21282
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    5-HT(2C) receptor agonist
    WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with a Ki of 10.5??1.1 nM. 了解更多
  13. Nelotanserin

    Catalog No. A21506
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    5-HT2A inverse agonist
    Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. 了解更多
  14. LY 344864 S-enantiomer

    Catalog No. A21742
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    5-HT1F receptor agonist
    LY 344864 S-enantiomer is the S-enantiomer of LY344864. LY344864 is a 5-HT1F receptor agonist. 了解更多
  15. LY 344864 hydrochloride

    Catalog No. A21748
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    5-HT1F agonist
    LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM. 了解更多
  16. Vilazodone D8

    Catalog No. A21876
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    SSR inhibitor / 5-HT1A receptor partial agonist
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多
  17. Aripiprazole (D8)

    Catalog No. A22004
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    human 5-HT1A receptor partial agonist
    Aripiprazole D8 (OPC-14597 D8) is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. 了解更多
  18. Mosapride citrate

    Catalog No. A10607
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    5-HT4-receptor 激动剂
    Mosapride citrate起5-HT4受体激动剂和5-HT3受体拮抗剂的作用。 了解更多
  19. Tianeptine sodium

    Catalog No. A10931
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    5-HT Receptor 激动剂
    Tianeptine钠是体内和体外的选择性5-羟色胺再摄取促进剂(SSRE)。 了解更多
  20. BMY 7378

    Catalog No. A11208
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    5-HT1A 激动剂
    BMY 7378是5-HT1A部分激动剂和高亲和力α1D肾上腺素能受体拮抗剂。 了解更多
  21. Prucalopride

    Catalog No. A11771
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    5-HT Receptor 激动剂
    Prucalopride是一种选择性的,高亲和力的5-HT4受体激动剂,作用于5-HT4A和5-HT4B受体,Ki分别为2.5 nM和8 nM,比作用于5-HT受体亚型选择性高290倍以上。 了解更多
  22. Naratriptan

    Catalog No. A10624
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    5-HT1 receptor
    Naratriptan是一种选择性的5-HT1受体亚型激动剂。 了解更多
  23. Clomipramine HCl

    Catalog No. A10231
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    5-HT Receptor 激动剂
    Clomipramine HCl是下列转运蛋白的阻滞剂:5-羟色胺转运蛋白 (SERT)(Ki = 0.14 nM),去甲肾上腺素转运蛋白(NET)(Ki = 54 nM),多巴胺转运蛋白(DAT)(Ki = 3,020 nM),甘氨酸转运蛋白(GlyT/LeuT)。 了解更多
  24. Almotriptan malate (Axert)

    Catalog No. A11799
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    5-HT Receptor 激动剂
    Almotriptan malate (Axert)是一种选择性的5-羟色胺1B/1D(5-HT1B/1D)受体激动剂,用于治疗成人偏头痛。 了解更多
  25. Aripiprazole (Abilify)

    Catalog No. A11801
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    5-HT1A receptor 激动剂
    Aripiprazole (Abilify)是人5-HT1A受体部分激动剂,Ki为4.2 nM。 了解更多
  26. Eletriptan hydrobromide

    Catalog No. A11418
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    5-HT1B/1D receptor 激动剂
    Eletriptan hydrobromide是一种选择性SR-1B/SR-1D激动剂。 了解更多
  27. Lorcaserin

    Catalog No. A12378
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    5-HT2C 激动剂
    Lorcaserin是一种新的选择性人5-羟色胺2c激动剂。 了解更多
  28. lorcaserin hydrochloride (APD-356)

    Catalog No. A12598
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    serotonin 2C receptor 激动剂
    lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂,可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。 了解更多
  29. RU 24969 hemisuccinate

    Catalog No. A13833
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    5-HT1A/1B and 5-HT2C 激动剂
    RU 24969 hemisuccinate是有效的5-HT1A/1B和中度5-HT2C激动剂,也可能释放5-HT。 了解更多
  30. S 32212 HCl

    Catalog No. A13501
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    5-HT2C 激动剂
    S 32212 HCl是5-HT2C受体的反向激动剂(人5-HT2C INI受体的pKi = 8.18)。 了解更多
  31. Eptapirone

    Catalog No. A15923
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    5HT(1A) receptor 激动剂
    Eptapirone是一种有效的,选择性的,高效的5-HT1A受体激动剂,具有显着的抗焦虑和抗抑郁潜力。 了解更多
  32. Pimavanserin

    Catalog No. A15884
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    Serotonin2A Receptor Inverse 激动剂
    Pimavanserin是一种有效的选择性5-羟色胺5-HT2A反向激动剂,pIC50为8.73,用于治疗与帕金森氏病有关的精神病。 了解更多
  33. YL-0919

    Catalog No. A16337
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    5-HT1A receptor 激动剂/serotonin reuptake 抑制剂
    YL0919,具有5-HT1A受体激动剂和选择性5-羟色胺再摄取抑制剂双重活性的新型抗抑郁候选药物,YL-0919抑制5-HT被大鼠大脑皮层突触小体和人重组细胞摄取的IC50值为1.78±0.34 nM和1.93±0.18 nM。 了解更多
  34. BRL-54443

    Catalog No. A15592
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    5-HT1E/5-HT1F receptor 激动剂
    BRL 54443是5-HT1E和5-HT1F受体激动剂,pKi分别为8.7和9.25,对5-HT1A,5-HT1B,5-HT1D受体的结合亲和力较弱。 了解更多
  35. Buspirone HCl

    Catalog No. A15687
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    5HT(1A) receptor 激动剂
    Buspirone hydrochloride是一种具有5-D(2)多巴胺能作用的血清素能(5HT(1A)受体激动剂)抗焦虑药,用于焦虑症。 了解更多
  36. LP-211

    Catalog No. A16898
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    5-HT7 receptor 激动剂
    LP-211是血清素5-HT7受体的选择性激动剂,在大鼠克隆的5-HT7受体上的Ki值为0.58 nM,选择性是5-HT1A受体的300倍以上。 了解更多
  37. Temanogrel

    Catalog No. A17094
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    5-HT(2A) receptor 激动剂
    Temanogrel,也称为APD791,是一种高度选择性的5-羟基色胺2A受体反向激动剂,正在开发中,用于治疗动脉血栓形成。 了解更多
  38. LY 344864 racemate

    Catalog No. A17015
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    5-HT1F receptor 激动剂
    LY 344864 racemate是5-HT1F受体激动剂。 了解更多
  39. Eptapirone (F-11440)

    Catalog No. A18338
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    5-HT1A receptor agonist
    Eptapirone is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone. 了解更多

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