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GPCR / G Protein

产品 151 到 200 共 385个

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  1. L-741626
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    L-741626

    Catalog No. A13694
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    D2 dopamine receptor 拮抗剂
    L-741626是一种有效且选择性的多巴胺受体D2拮抗剂。它对相关的D3和D4亚型以及其他受体具有良好的选择性。 了解更多
  2. SB269652
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    SB269652

    Catalog No. A14191
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    Dopamine D2 Receptor 拮抗剂
    SB269652是一种新的化学探针，可根据观察到的药理学将D2R单体与二聚体或低聚物区分开来。 了解更多
  3. Metoclopramide HCl
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    Metoclopramide HCl

    Catalog No. A14247
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    dopamine D2 receptor 拮抗剂
    Metoclopramide HCl是一种选择性的多巴胺D2受体拮抗剂。 了解更多
  4. SCH 23390 HCl
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    SCH 23390 HCl

    Catalog No. A13066
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    D1/D5 receptor 拮抗剂
    SCH 23390 HCl是一种有效的多巴胺受体拮抗剂（D1和D5受体亚型的Ki值分别为0.2 nM和0.3 nM）。 了解更多
  5. Sulpiride
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    Sulpiride

    Catalog No. A16133
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    dopamine D2-receptor 拮抗剂
    Sulpiride是一种多巴胺D2受体拮抗剂。它已在治疗上用作抗抑郁药，抗精神病药和消化助剂。 了解更多
  6. Prochlorperazine
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    Prochlorperazine

    Catalog No. A16172
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    dopamine (D2) receptor 拮抗剂
    Prochlorperazine是一种多巴胺（D2）受体拮抗剂，属于抗精神病药的吩噻嗪类。 了解更多
  7. Alizapride HCl
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    Alizapride HCl

    Catalog No. A16394
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    Dopamine receptor 拮抗剂
    Alizapride HCl是一种多巴胺受体拮抗剂，用于治疗恶心和呕吐。 了解更多
  8. Azaperone
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    Azaperone

    Catalog No. A16416
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    Dopamine receptor 拮抗剂
    Azaperone是一种具有镇静和止吐作用的吡啶基哌嗪和丁苯酮类抗精神病药，主要在兽药中用作镇定剂。 了解更多
  9. Pimozide
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    Pimozide

    Catalog No. A17375
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    Dopamine receptor antagonist
    Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5. 了解更多
  10. Melitracen hydrochloride
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    Melitracen hydrochloride

    Catalog No. A17494
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    dopamine D1/2 receptor antagonist
    Melitracen HCl ia potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function. 了解更多
  11. Metoclopramide hydrochloride hydrate
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    Metoclopramide hydrochloride hydrate

    Catalog No. A18072
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    Dopamine D2 antagonist
    Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic. 了解更多
  12. A-381393
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    A-381393

    Catalog No. A18784
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    Dopamine D4 receptor antagonist
    A-381393 is a potent and selective agonist of the dopamine D4 receptor. 了解更多
  13. NRA-0160
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    NRA-0160

    Catalog No. A20128
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    Dopamine D4 receptor antagonist
    NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM). 了解更多
  14. LY2795050
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    LY2795050

    Catalog No. A15149
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    k-opioid receptor 拮抗剂
    LY2795050是新型选择性κ阿片受体（KOR）拮抗剂（IC50 = 0.72 nM），具有作为PET示踪剂在体内对KOR成像的潜力。 了解更多
  15. Methylnaltrexone Bromide
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    Methylnaltrexone Bromide

    Catalog No. A15159
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    μ-opioid 拮抗剂
    Methylnaltrexone Bromide是一种作用于胃肠道以减少阿片类药物引起的便秘的具有信息素作用的?-opioid拮抗剂。 了解更多
  16. GSK1521498 free base
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    GSK1521498 free base

    Catalog No. A18994
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    μ-opioid receptor antagonist
    GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs. 了解更多
  17. JDTic
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    JDTic

    Catalog No. A11468
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    κ-opioid receptor antagonist
    JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. 了解更多
  18. GSK1521498 free base (hydrochloride)
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    GSK1521498 free base (hydrochloride)

    Catalog No. A21792
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    μ-opioid receptor (MOR) antagonist
    GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist. 了解更多
  19. JTC-801
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    JTC-801

    Catalog No. A11076
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    Opioid Receptor 拮抗剂
    JTC-801是nociceptin receptor（也称为ORL-1受体）的选择性拮抗剂。 了解更多
  20. Alvimopan (ADL 8-2698)
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    Alvimopan (ADL 8-2698)

    Catalog No. A11292
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    Opioid 拮抗剂
    Alvimopan (ADL 8-2698)表现为外周作用的opioid拮抗剂，Alvimopan竞争性结合胃肠道中的mu-opioid receptor。 了解更多
  21. BAN ORL 24
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    BAN ORL 24

    Catalog No. A11322
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    NOP 拮抗剂
    BAN ORL 24是一种强效选择性NOP受体拮抗剂。 了解更多
  22. Naloxegol Oxalate
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    Naloxegol Oxalate

    Catalog No. A15972
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    Opioid 拮抗剂
    Naloxegol Oxalate是用于治疗阿片类药物引起的便秘的外周选择性阿片类药物拮抗剂。 了解更多
  23. BTRX-335140
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    BTRX-335140

    Catalog No. A18583
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    κ opioid receptor antagonist
    BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. 了解更多
  24. MTEP hydrochloride
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    MTEP hydrochloride

    Catalog No. A15174
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    mGlu5 拮抗剂
    MTEP hydrochloride是一种有效的，选择性和非竞争性的mGlu5拮抗剂，IC50和Ki分别为5 nM和16 nM。 了解更多
  25. DL-AP3
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    DL-AP3

    Catalog No. A15378
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    mGluR1 拮抗剂
    DL-AP3是D-AP3和L-AP3的外消旋制剂，是磷酸丝氨酸磷酸酶的抑制剂和代谢型谷氨酸受体（mGluR）的拮抗剂，阻断了由mGluR介导的磷酸肌醇转换。 了解更多
  26. Dipraglurant
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    Dipraglurant

    Catalog No. A11382
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    mGluR5 antagonists
    Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. 了解更多
  27. Mavoglurant
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    Mavoglurant

    Catalog No. A21223
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    mGlu5 receptor antagonist
    Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. 了解更多
  28. LY 541850
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    LY 541850

    Catalog No. A21651
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    mGlu2 agonist/mGlu3 antagonist
    LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively. 了解更多
  29. Mavoglurant racemate
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    Mavoglurant racemate

    Catalog No. A21799
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    mGlu5 receptor antagonist
    Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. 了解更多
  30. Methoxy-PEPy
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    Methoxy-PEPy

    Catalog No. A21899
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    mGlu5 receptor antagonist
    Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. 了解更多
  31. Auglurant
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    Auglurant

    Catalog No. A20958
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    mGlu5 antagonist
    Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration. 了解更多
  32. MPEP
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    MPEP

    Catalog No. A12589
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    mGlu5 receptor 拮抗剂
    MPEP是mGlu5受体亚型（IC50 = 36 nM）的有效且高度选择性的非竞争性拮抗剂，并且是mGlu4受体的正构构调节剂。 了解更多
  33. PHCCC
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    PHCCC

    Catalog No. A12705
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    mGluR 拮抗剂
    PHCCC是I组代谢型谷氨酸受体拮抗剂（IC50?3μM）。 了解更多
  34. SIB 1893
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    SIB 1893

    Catalog No. A13759
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    mGluR 拮抗剂
    SIB 1893是代谢型谷氨酸mGlu5受体亚型的高度选择性非竞争性拮抗剂。 了解更多
  35. SIB 1757
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    SIB 1757

    Catalog No. A13758
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    mGluR 拮抗剂
    SIB 1757是mGlu5代谢型谷氨酸受体亚型的高度选择性拮抗剂。 了解更多
  36. MPEP HCl
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    MPEP HCl

    Catalog No. A13236
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    mGlu5 receptor 拮抗剂
    MPEP HCl是对mGlu5a受体亚型（IC50 = 36 nM）的有效，高度选择性的非竞争性拮抗剂，但在浓度高达30 uM的mGlu1b受体上无激动剂或拮抗剂活性。 了解更多
  37. LY341495
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    LY341495

    Catalog No. A11484
    mGluR-2 拮抗剂
    LY 341495已被证明是一种高效的选择性II类代谢型谷氨酸受体(mGluR-2)拮抗剂，对于人类mGluR-2，mGluR，Ki/IC50值分别为2.3、1.3、173、990、6800、8200和22000 nM。mGluR-3，mGluR-8，mGluR-7a，mGluR-1a，mGluR-5a和mGluR-4a。 了解更多
  38. A-841720
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    A-841720

    Catalog No. A13854
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    mGluR-1 拮抗剂
    841720是一种有效的非竞争性mGluR-1拮抗剂，相对于mGluR-5具有34倍的选择性（IC50值分别为10和342 nM）。 了解更多
  39. LY2940680 (Taladegib)
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    LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO 拮抗剂
    LY2940680 (Taladegib)已显示可影响由Hedgehog（Hh）蛋白引发的癌细胞信号通路。 了解更多
  40. ALLO-2
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    ALLO-2

    Catalog No. A18698
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    Smo mutant antagonist
    ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. 了解更多
  41. MRT-83
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    MRT-83

    Catalog No. A21020
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    Smo antagonist
    MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. 了解更多
  42. LDE225 (NVP-LDE225, Sonidegib)
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    LDE225 (NVP-LDE225, Sonidegib)

    Catalog No. A10520
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    Smo 拮抗剂
    LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。 了解更多
  43. SCH 563705
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    SCH 563705

    Catalog No. A15234
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    CXCR2/CXCR1 拮抗剂
    SCH 563705是有效的双重CXCR2（IC50 = 1.3 nM)/CXCR1（IC50 = 7.3 nM）拮抗剂。 了解更多
  44. AZD-5069
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    AZD-5069

    Catalog No. A15941
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    CXCR2 拮抗剂
    AZD-5069是一种有效的选择性CXCR2拮抗剂，具有抑制COPD患者中性粒细胞向气管迁移的潜能。 了解更多
  45. AMG 487
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    AMG 487

    Catalog No. A21162
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    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多
  46. SCH 546738
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    SCH 546738

    Catalog No. A21554
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    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多
  47. AMG 487 S-enantiomer
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    AMG 487 S-enantiomer

    Catalog No. A21874
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    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多
  48. NBI-74330
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    NBI-74330

    Catalog No. A21158
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    CXCR3 antagonist
    NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. 了解更多
  49. Plerixafor 8HCl (DB06809)
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    Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 拮抗剂
    Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导调节的趋化性， IC50分别为44 nM和5.7 nM。 了解更多
  50. AMD 070
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    AMD 070

    Catalog No. A11315
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    CXCR4 拮抗剂
    AMD 070是CXCR4趋化因子受体拮抗剂。 了解更多

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