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￥ 0.00 GPCR / G Protein
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CXCR2-IN-1
Catalog No. A12649 CXCR2 激动剂CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. 了解更多 -
SCH 563705
Catalog No. A15234 -
AZD-5069
Catalog No. A15941 -
GPR35 agonist 1
Catalog No. A12462 GPR35/CXCR8 agonistGPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多 -
Kynurenic acid sodium
Catalog No. A20000 GPR35/CXCR8 agonistKynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多 -
SCH 546738
Catalog No. A21554 CXCR3 antagonistSCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多 -
AMG 487 S-enantiomer
Catalog No. A21874 CXCR3 antagonistAMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多 -
LDE225 (NVP-LDE225, Sonidegib)
Catalog No. A10520 Smo 拮抗剂LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。 了解更多 -
LY2940680 (Taladegib)
Catalog No. A11048 -
LDE225 Diphosphate
Catalog No. A12774 Smoothened 抑制剂LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑（Smo）拮抗剂。抑制Hedgehog (Hh)信号通路，无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。 了解更多 -
PF-5274857
Catalog No. A12775 Smoothened 抑制剂PF-5274857是一种新型Smo拮抗剂，它以4.6±1.1 nmol/L的K（i）特异性结合Smo，并以2.7±1.4 nmol/L的IC（50）完全阻断下游基因Gli1的转录活性。在细胞中。 了解更多 -
BMS-833923 (XL-139)
Catalog No. A13204 Smoothened 抑制剂BMS-833923 (XL-139)是一种生物可利用的小分子SMO(平滑)抑制剂，具有潜在的抗肿瘤活性。 了解更多 -
Glasdegib (PF-04449913)
Catalog No. A13881 -
SAG
Catalog No. A13627 -
Jervine
Catalog No. A16221 -
SAG hydrochloride
Catalog No. A21678 Smo receptor agonistSAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM. 了解更多 -
20(S)-Hydroxycholesterol
Catalog No. A21850 Smo allosteric activator20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells. 了解更多 -
Melanotan II
Catalog No. A12646 Melanotan II是一种高亲和力的黑皮质素受体激动剂（MC1，MC4，MC3和MC5受体的Ki值分别为0.67、6.6、34和46 nM）。 了解更多 -
Parathyroid Hormone 1-34, Human
Catalog No. A12790 Parathyroid Hormone 1-34, Human包含hPTH的34个N端残基。 甲状旁腺1（PTH1）和甲状旁腺2（PTH2）受体的激动剂，其在 HEK293 细胞中的 IC50 值为 2 nM。 了解更多 -
Prostaglandin E1 (PGE1)
Catalog No. A11820 Prostaglandin E1 (PGE1)是理论上的二高纯-γ-亚麻酸（DGLA）的环氧合酶代谢产物，但在正常人或其他动物的血浆中几乎无法检测到。PGE1抑制ADP诱导的人血小板聚集的IC50为40 nM。 了解更多 -
Melatonin
Catalog No. A10564 -
Ramelteon (TAK-375)
Catalog No. A10777 MT1/MT2-Receptor 激动剂Ramelteon (TAK-375)是melatonin受体激动剂，对褪黑激素MT1（IC50 = 28.5±8.55 pM）和MT2（20.1±9.25 pM）受体均具有高亲和力，并且相对于MT3受体具有选择性。 了解更多 -
Tasimelteon
Catalog No. A17351 MT1 and MT2 receptor agonistTasimelteon is a melatonin MT1 and MT2 receptor agonist. 了解更多 -
ADX-47273
Catalog No. A11181 -
LY2140023 (LY404039)
Catalog No. A10544 mGluR 激动剂LY-404039是一种用于科学研究的药物，用作代谢型谷氨酸受体II亚型mGluR2和mGluR3的选择性激动剂。它在动物研究中具有抗焦虑和抗精神病作用，但不会引起镇静作用。早期的人体试验使用LY-404，039前药形式LY-214，0023，也取得了令人鼓舞的结果。 了解更多 -
VU 0357121
Catalog No. A11754 -
VU 0364439
Catalog No. A12664 -
SIB 1757
Catalog No. A13758 -
VU 0361737
Catalog No. A12467 mGlu4 receptors modulatorVU 0361737是mGluR-4的选择性正变构调节剂（人和大鼠受体的EC50值分别为240和110 nM）。 了解更多 -
A-841720
Catalog No. A13854
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