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A 803467是NaV1.8通道的选择性阻滞剂（hNaV1.8，hNaV1.3，hNaV1.7，hNaV1.5和hNaV1.2通道的IC50值分别为8、2450、6740、7340和7380 nM）。
靶点信息
| Na(V1.8) channel | ||||
| 8 nM |
| In vitro (25°C) | DMSO | 64 mg/mL (178.87 mM) | |
| Water | Insoluble | ||
| Ethanol | 10 mg/mL (27.95 mM) | ||
| In vivo | 2% DMSO+corn oil | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.95 mL | 139.74 mL | 279.49 mL |
| 0.5 mM | 5.59 mL | 27.95 mL | 55.9 mL |
| 1 mM | 2.79 mL | 13.97 mL | 27.95 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.59 mL |
*The above data is based on the productmolecular weight 357.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11234 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 357.8 |
| Formula | C19H16ClNO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 944261-79-4 |
| Synonyms | A-803467, A803467 |
| SMILES | COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC |
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