产品详情
A66的S对映异构体是PI 3-激酶(PIK3CA)的p110alpha亚型的有效抑制剂。无细胞试验中IC50为32 nM,作用于p110α比作用于其他I类PI3K亚型选择性高100多倍。
In vitro (25°C) | DMSO | 77 mg/mL (195.66 mM) | |
Water | Insoluble | ||
Ethanol | 1 mg/mL (2.54 mM) | ||
In vivo | 15% Captisol | 7 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.41 mL | 127.06 mL | 254.11 mL |
0.5 mM | 5.08 mL | 25.41 mL | 50.82 mL |
1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A11202 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 393.53 |
Formula | C17H23N5O2S2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1166227-08-2 |
Synonyms | A-66 |
SMILES | CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CSC(=N3)C(C)(C)C |
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