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ACP-196 (Acalabrutinib)

ACP-196 (Acalabrutinib)

Name: ACP-196 (Acalabrutinib)
SKU: A15824

目录号: A15824

Btk 抑制剂

ACP-196 (Acalabrutinib) Chemical Structure

CAS NO. 1420477-60-6

ACP-196是Bruton酪氨酸激酶（BTK）抑制剂，具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体（BCR）信号传导途径的激活。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 490.00
25 mg	￥ 700.00

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产品详情

生物活性

ACP-196是Bruton酪氨酸激酶（BTK）抑制剂，具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体（BCR）信号传导途径的激活。

靶点信息

BTK
3nM

溶解度 *

In vitro (25°C)	DMSO	80 mg/mL (171.85 mM)
	Water	Insoluble
	Ethanol	80 mg/mL (171.85 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.41 mL	214.81 mL
0.5 mM	4.3 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15824
作用机制	Inhibitor (抑制剂)
M. Wt	465.52
Formula	C26H23N7O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1420477-60-6
Synonyms	Acalabrutinib, ACP196, ACP 196
SMILES	CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5