Adrenergic Receptors

Quick View
Apalutamide (ARN-509)

Catalog No. A11923
Quick View

添加到收藏
Androgen Receptor 抑制剂

Apalutamide (ARN-509)是一种具有潜在抗肿瘤活性的雄激素受体拮抗剂，IC50 为 16 nM。ARN-509与靶组织中的AR结合，从而阻止了雄激素诱导的受体激活，并促进了无法转运至细胞核的无活性复合物的形成。这防止了AR应答基因的结合和转录。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Frédérique Mittler, .et al. High-Content Monitoring of Drug Effects in a 3D Spheroid Model, Front Oncol, 2017, 7: 293 PMID: 29322028
Quick View
Phenoxybenzamine hydrochloride

Catalog No. A10719
Quick View

添加到收藏
α-adrenergic (AR) 拮抗剂/CaM 抑制剂

Phenoxybenzamine hydrochloride是一种细胞可渗透的，非特异性的，不可逆的α-肾上腺素（AR）拮抗剂，也可作为CaM抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Maprotiline hydrochloride

Catalog No. A10555
Quick View

添加到收藏
noradrenalin re-uptake 抑制剂

Maprotiline hydrochloride是选择性去甲肾上腺素再摄取抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Asenapine HCl

Catalog No. A15002
Quick View

添加到收藏
adrenergic receptor/5-HT receptor 抑制剂

Asenapine hydrochloride抑制肾上腺素能受体（α1，α2A，α2B，α2C）的Ki为0.25-1.2 nM，还抑制5-HT受体（1A，1B，2A，2B，2C，5A，6、7），Ki为0.03- 4.0 nM。了解更多

Bulk Inquiry
Quick View
Desvenlafaxine succinate hydrate

Catalog No. A15491
Quick View

添加到收藏
serotonin (5-HT)/norepinephrine (NE) reuptake 抑制剂

Desvenlafaxine succinate hydrate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM 了解更多

Bulk Inquiry
Quick View
Anisodamine

Catalog No. A18215
Quick View

添加到收藏
alpha-1 adrenergic receptors / mAChRs inhibitor

Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. 了解更多

Bulk Inquiry
Quick View
Asenapine

Catalog No. A18010
Quick View

添加到收藏
adrenergic receptor inhibitor

Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM. 了解更多

Bulk Inquiry