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AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.42 mL | 72.08 mL | 144.16 mL |
| 0.5 mM | 2.88 mL | 14.42 mL | 28.83 mL |
| 1 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
*The above data is based on the productmolecular weight 693.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19087 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 693.66 |
| Formula | C33H29F6N3O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2361659-61-0 |
| Synonyms | AES135, AES 135 |
| SMILES | CC(C)(C)C1=CC=C(CN(C(CN(CC2=C(F)C(F)=C(F)C(F)=C2F)S(=O)(C3=CC=C(F)C=C3)=O)=O)C4=CC=C(C(NO)=O)C=C4)C=C1 |
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