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Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
| In vitro (25°C) | DMSO | 90 mg/mL (185.21 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (28.8 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.58 mL | 102.89 mL | 205.79 mL |
| 0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
| 1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18014 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 485.94 |
| Formula | C24H25ClFN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 850140-72-6 |
| Synonyms | BIBW 2992, BIBW-2992, BIBW2992 |
| SMILES | O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C)C |
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