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Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.
| In vitro | DMSO | 53 mg/mL (187.08 mM) | |
| Water | Insoluble | ||
| Ethanol | 27 mg/mL (95.3 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.3 mL | 176.49 mL | 352.97 mL |
| 0.5 mM | 7.06 mL | 35.3 mL | 70.59 mL |
| 1 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
*The above data is based on the productmolecular weight 283.3064. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17276 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 283.3064 |
| Formula | C16H14FN3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 56287-74-2 |
| Synonyms | HQ-495; HQ495; HQ 495. Afloqualone |
| SMILES | O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3 |
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