微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
Afuresertib HCl，也称为GSK2110183，是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B）的生物利用抑制剂。它结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关，PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.56 mL | 107.81 mL | 215.62 mL |
| 0.5 mM | 4.31 mL | 21.56 mL | 43.12 mL |
| 1 mM | 2.16 mL | 10.78 mL | 21.56 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
*The above data is based on the productmolecular weight 463.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13030 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 463.78 |
| Formula | C18H18Cl3FN4OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1047645-82-8 |
| Synonyms | GSK2110183, GSK 2110183 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
GDC-0068 (Ipatasertib, RG-7440)
GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3…
ARQ-092 (Miransertib)
ARQ 092是一种口服活化，有效和选择性的AKT抑制剂，IC50值：5.0 nM（AKT1）；4.5 nM（AKT2）；16 nM（AKT3）。
Palomid 529 (P529)
Palomid 529是PI3K/Akt/mTOR途径的双重TORC1/2抑制剂，在血管生成和细胞增殖中具有广泛的活性。
Keywords:购买 Afuresertib HCl | Afuresertib HCl 供应商 | 订购 Afuresertib HCl | Afuresertib HCl 价格 | Afuresertib HCl 生产商 | 订单 Afuresertib HCl | Afuresertib HCl 代理商 | 购买 1047645-82-8| 1047645-82-8 供应商 | 订购 1047645-82-8 | 1047645-82-8 价格 | 1047645-82-8 生产商 | 订单 1047645-82-8 | 1047645-82-8 代理商|buy Afuresertib HCl | Afuresertib HCl Supplier | purchase Afuresertib HCl | Afuresertib HCl cost | Afuresertib HCl manufacturer | order Afuresertib HCl | Afuresertib HCl distributor | buy 1047645-82-8| 1047645-82-8 Supplier | purchase 1047645-82-8 | 1047645-82-8 cost | 1047645-82-8 manufacturer | order 1047645-82-8 | 1047645-82-8 distributor