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AMG 232是MDM2-p53相互作用的高效，选择性生物利用的哌啶酮抑制剂（SPR KD = 0.045 nM，SJSA-1 EdU IC50 = 9.1 nM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.59 mL | 87.94 mL | 175.89 mL |
| 0.5 mM | 3.52 mL | 17.59 mL | 35.18 mL |
| 1 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
*The above data is based on the productmolecular weight 568.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14394 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 568.55 |
| Formula | C28H35Cl2NO5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1352066-68-2 |
| Synonyms | AMG-232, AMG 232 |
| SMILES | CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl |
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