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AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。
| In vitro | DMSO | 47 mg/mL (187.21 mM) | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.83 mL | 199.14 mL | 398.28 mL |
| 0.5 mM | 7.97 mL | 39.83 mL | 79.66 mL |
| 1 mM | 3.98 mL | 19.91 mL | 39.83 mL |
| 5 mM | 0.8 mL | 3.98 mL | 7.97 mL |
*The above data is based on the productmolecular weight 251.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12776 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 251.08 |
| Formula | C14H10BNO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 906673-24-3 |
| Synonyms | AN 2728, AN-2728 |
| SMILES | B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O |
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