主页 /
Angiogenesis

Angiogenesis

Angiogenesis is the formation and remodelling of new blood vessels and capillaries from growth of pre-existing blood vessels. It normally occurs during wound healing and embryonic development, but is also required for tumour growth and metastasis in cancer.

Quick View
CEP-37440

Catalog No. A15543
Quick View

添加到收藏
FAK/ALK 抑制剂

CEP-37440是一种新型的高效选择性FAK/ALK双重抑制剂，IC50为2.3 nM（FAK）和120 nM（ALK细胞在50％人血浆中的IC50。了解更多

Bulk Inquiry
Quick View
PF 573228

Catalog No. A11235
Quick View

添加到收藏
FAK 抑制剂

PF 573228是一种有效和选择性的粘着斑激酶（FAK）抑制剂（IC50 = 4 nM）。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
- Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208
Quick View
PF-04554878 (Defactinib)

Catalog No. A11929
Quick View

添加到收藏
FAK 抑制剂

PF-04554878 (Defactinib)是一种新型FAK激酶抑制剂，可降低胰腺神经内分泌肿瘤细胞的生长并诱导其凋亡。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Shalana O'Brien, .et al. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics, Oncotarget., 2014, Sep; 5(17): 7945-7959. PMID: 25277206
Quick View
PF-562271

Catalog No. A11192
Quick View

添加到收藏
FAK 抑制剂

PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Jiping Yue, .et al. In vivo epidermal migration requires focal adhesion targeting of ACF7, Nat Commun, 2016, 7: 11692 PMID: 27216888
Quick View
NVP-TAE 226

Catalog No. A11507
Quick View

添加到收藏
FAK 抑制剂

NVP-TAE 226是一种强效FAK抑制剂，IC50为5.5 nM，对pyk2(IC50=3.5 nM)有适度的强效作用；对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。了解更多

Bulk Inquiry Free Sample
Quick View
PF-03814735

Catalog No. A11171
添加到收藏
Aurora A/B Kinase 抑制剂

PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。了解更多

Bulk Inquiry
Quick View
PF-4618433

Catalog No. A13461
Quick View

添加到收藏
PYK2/FAK 抑制剂

PF-4618433与原型BIRB796相比，PF-4618433显示出PYK2效价提高、p38活性降低和总体选择性优越。了解更多

Bulk Inquiry
Quick View
PF-00562271

Catalog No. A12580
Quick View

添加到收藏
FAK 抑制剂

PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK和Pyk2抑制剂，IC50分别为1.5 nM和14 nM。了解更多

Bulk Inquiry
Quick View
PF 431396

Catalog No. A11142
Quick View

添加到收藏
FAK/PYK2 抑制剂

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。了解更多

Bulk Inquiry Free Sample
Quick View
PND-1186

Catalog No. A13140
Quick View

添加到收藏
FAK 抑制剂

PND-1186是一种强效fak抑制剂，ic50为1.5 nm。了解更多

Bulk Inquiry