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ANX-510是基于叶酸的生物调节剂，具有潜在的抗肿瘤活性。5,10-亚甲基四氢叶酸（MTHF）稳定氟尿嘧啶代谢物5-5-氟-2'-脱氧尿苷-5'-O-单磷酸酯（FdUMP）与目标酶胸苷酸合酶的共价结合，从而抑制胸苷酸合酶，三磷酸胸苷的消耗（TTP），DNA的必要成分以及肿瘤细胞死亡。与亚叶酸钙不同，作为叶酸的活性形式的MTHF不需要代谢活化，并且可以提高氟尿嘧啶的化学治疗效果，且毒性较低。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.3 mL | 218.61 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.72 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12370 |
|---|---|
| M. Wt | 457.44 |
| Formula | C20H23N7O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 3432-99-3 |
| Synonyms | ANX510; CoFactor; 5,10-methylenetetrahydrofolate; 5,10-Methylene-5,6,7,8-tetrahydrofolate; 5,10-MTHF; MTHF |
| SMILES | C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
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