AR-C155858

Name: AR-C155858
SKU: A11293

目录号: A11293

MCT1 and MCT2 抑制剂

Product Citations (6)

AR-C155858 Chemical Structure

CAS NO. 496791-37-8

AR-C155858是单羧酸转运蛋白mct1和mct2的有效抑制剂，它们与涉及跨膜螺旋7-10的细胞内位点结合。

库存：现货

规格	价格	数量
5 mg	￥ 2,520.00
10 mg	￥ 4,200.00
25 mg	￥ 8,400.00

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生物活性

AR-C155858是单羧酸转运蛋白mct1和mct2的有效抑制剂，它们与涉及跨膜螺旋7-10的细胞内位点结合。

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.67 mL	108.34 mL	216.68 mL
0.5 mM	4.33 mL	21.67 mL	43.34 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL

*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11293
作用机制	Inhibitor (抑制剂)
M. Wt	461.5
Formula	C21H27N5O5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	496791-37-8
Synonyms	AR-C 155858
SMILES	CC1=C(C(=NN1)C)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)CC(C)C)C(=O)N4C[C@@H](CO4)O

参考文献

1. Ovens et al (2010) The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem.J. 431 217. PMID: 20695846.

2.Ovens et al (2010) AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem.J. 425 523. PMID: 19929853.