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Arry-380 analog是一种ErbB-2抑制剂，可选择性结合并抑制ErbB-2的磷酸化，从而导致表达ErbB-2的肿瘤细胞的生长抑制和死亡。
| In vitro | DMSO | 90 mg/mL (158 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (5.26 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.55 mL | 87.73 mL | 175.47 mL |
| 0.5 mM | 3.51 mL | 17.55 mL | 35.09 mL |
| 1 mM | 1.75 mL | 8.77 mL | 17.55 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
*The above data is based on the productmolecular weight 569.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11027 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 569.9 |
| Formula | C29H27N7O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 937265-83-3 |
| Synonyms | Arry380 |
| SMILES | CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CNCCS(=O)(=O)C)OC5=CC6=NC=NN6C=C5 |
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