产品详情

生物活性

AS-252424是有效的PI3K抑制剂，对γ亚型具有选择性。它抑制人重组PI3Kγ，α，β和δ，IC50值分别为30、940、20,000和20,000 nM。

靶点信息

Casein Kinase 2 (Cell-free assay)	PI3Kγ (Cell-free assay)	PI3Kα (Cell-free assay)
20 nM	33 nM	935 nM

溶解度 *

In vitro (25°C)	DMSO	57 mg/mL (186.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.75 mL	163.77 mL	327.55 mL
0.5 mM	6.55 mL	32.75 mL	65.51 mL
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11099
作用机制	Inhibitor (抑制剂)
M. Wt	305.3
Formula	C14H8FNO4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	900515-16-4
Synonyms	AS252424
SMILES	C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3