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AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.34 mL | 121.72 mL | 243.45 mL |
| 0.5 mM | 4.87 mL | 24.34 mL | 48.69 mL |
| 1 mM | 2.43 mL | 12.17 mL | 24.34 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.87 mL |
*The above data is based on the productmolecular weight 410.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15006 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 410.77 |
| Formula | C20H22Cl3N3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1431697-86-7 |
| Synonyms | AT-7867 dihydrochloride, AT 7867 dihydrochloride |
| SMILES | C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
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