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AT7867是AKT和下游激酶p70 S6激酶（p70S6K）以及蛋白激酶A的新型有效抑制剂。
Targets
| Target | Value |
|---|---|
| Akt2 | IC50: 17nM |
| PKA | IC50: 20nM |
| Akt1 | IC50: 32nM |
| Akt3 | IC50: 47nM |
| p70S6K | IC50: 85nM |
| RSK1 | IC50: >100nM |
| CDK2 | IC50: >1μM |
| GSK-3β | IC50: >1μM |
| c-Src | IC50: >1μM |
| Chk1 | IC50: >1μM |
| EGFR | IC50: >1μM |
| FGFR3 | IC50: >1μM |
| MEK1 | IC50: >1μM |
| PDK-1 | IC50: >1μM |
| PI3Kβ | IC50: >1μM |
| PLK3 | IC50: >1μM |
| RET | IC50: >1μM |
| SGK | IC50: >1μM |
| Tie-2 | IC50: >1μM |
| In vitro (25°C) | DMSO | 63 mg/mL (186.47 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (14.79 mM) | ||
| In vivo | 15% Captisol, pH 9 | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.59 mL | 147.97 mL | 295.95 mL |
| 0.5 mM | 5.92 mL | 29.59 mL | 59.19 mL |
| 1 mM | 2.96 mL | 14.8 mL | 29.59 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.92 mL |
*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10094 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 337.9 |
| Formula | C20H20ClN3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 857531-00-1 |
| Synonyms | AT-7867 |
| SMILES | C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl |
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