Autophagy

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Spautin-1

Catalog No. A12942
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Autophagy 抑制剂

Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。了解更多

Product Citations (1)

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- Yoon-Jin Kim, .et al. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system, Sci Adv, 2021, Feb 19;7(8) PMID: 33608268
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SBI-0206965

Catalog No. A15795
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ULK1 抑制剂

SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。了解更多

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- SR Bonam, .et al. Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo, Cells, 2020, May; 9(5): 1321 PMID: 32466347
- Altea Rocchi, .et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease, PLoS Genet, 2017, Aug; 13(8): e1006962 PMID: 28806762
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MRT68921

Catalog No. A15880
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Autophagy ULK1/2 抑制剂

MRT68921是一种有效的双重自噬激酶ULK1/2抑制剂，IC50分别为2.9 nM和1.1 nM。了解更多

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Lys05

Catalog No. A16358
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Autophagy 抑制剂

Lys05是有效的溶酶体自噬抑制剂。Lys05是一种先前未描述的二聚氯喹，与HCQ相比，它更有效地积聚在溶酶体中并阻止自噬。了解更多

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IITZ-01

Catalog No. A20192
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Lysosomotropic autophagy inhibitor

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. 了解更多

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EACC

Catalog No. A19062
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Autophagy inhibitor

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. 了解更多

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Aumitin

Catalog No. A18838
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Autophagy inhibitor

Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. 了解更多

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Lys01 trihydrochloride

Catalog No. A21702
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lysosomal autophagy inhibitor

Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. 了解更多

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Autophinib

Catalog No. A17241
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Autophagy inhibitor

Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. 了解更多

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ROC-325

Catalog No. A17031
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Autophagy 抑制剂

ROC-325是自噬抑制剂。与现有的自噬抑制剂羟氯喹（HCQ）相比，ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。了解更多

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Monensin sodium

Catalog No. A10603
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ionophore

Monensin sodium是一种离子载体，是自噬在牲畜饲料中的抑制剂。它抑制自噬，干扰自噬体和溶酶体的融合。了解更多

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PIK-III

Catalog No. A15868
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Autophagy 抑制剂

PIK-III是βVPS34酶活性的选择性抑制剂。了解更多

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3-Methyladenine

Catalog No. A11151
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Autophagy/PI3K 抑制剂

3-Methyladenine是III类磷脂酰肌醇3-激酶（PI 3-激酶）的抑制剂。了解更多

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