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Autophagy

25 个项目

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  1. Lys01 trihydrochloride
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    Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. 了解更多
  2. QX77
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    QX77

    Catalog No. A13379
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    autophagy (CMA) activator
    QX77 is a chaperone-mediated autophagy (CMA) activator. 了解更多
  3. EN6
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    EN6

    Catalog No. A18524
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    Autophagy activator
    EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. 了解更多
  4. Aumitin
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    Aumitin

    Catalog No. A18838
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    Autophagy inhibitor
    Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. 了解更多
  5. EACC
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    EACC

    Catalog No. A19062
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    Autophagy inhibitor
    EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. 了解更多
  6. IITZ-01
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    IITZ-01

    Catalog No. A20192
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    Lysosomotropic autophagy inhibitor
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. 了解更多
  7. ALLO-1
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    ALLO-1

    Catalog No. A18670
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    autophagy receptor
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. 了解更多
  8. Autophinib
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    • 最新产品

    Autophinib

    Catalog No. A17241
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    Autophagy inhibitor
    Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. 了解更多
  9. ROC-325
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    ROC-325

    Catalog No. A17031
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    Autophagy 抑制剂
    ROC-325是自噬抑制剂。与现有的自噬抑制剂羟氯喹（HCQ）相比，ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。 了解更多
  10. Monensin sodium
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    Monensin sodium

    Catalog No. A10603
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    ionophore
    Monensin sodium是一种离子载体，是自噬在牲畜饲料中的抑制剂。它抑制自噬，干扰自噬体和溶酶体的融合。 了解更多
  11. PIK-III
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    PIK-III

    Catalog No. A15868
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    Autophagy 抑制剂
    PIK-III是βVPS34酶活性的选择性抑制剂。 了解更多
  12. SMER28
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    SMER28

    Catalog No. A15867
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    Autophagy Activator
    SMER28是自噬的小分子增强剂（SMER），在哺乳动物细胞中独立于雷帕霉素诱导自噬。 了解更多
  13. 3-Methyladenine
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    3-Methyladenine

    Catalog No. A11151
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    Autophagy/PI3K 抑制剂
    3-Methyladenine是III类磷脂酰肌醇3-激酶（PI 3-激酶）的抑制剂。 了解更多
  14. Scutellarein
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    Scutellarein

    Catalog No. A12234
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    Scutellarein是从灯盏细辛中提取的主要活性成分。 了解更多
  15. Lys05
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    Lys05

    Catalog No. A16358
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    Autophagy 抑制剂
    Lys05是有效的溶酶体自噬抑制剂。Lys05是一种先前未描述的二聚氯喹，与HCQ相比，它更有效地积聚在溶酶体中并阻止自噬。 了解更多
  16. Azithromycin Dihydrate
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    Azithromycin Dihydrate

    Catalog No. A16421
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    Azithromycin Dihydrate是一种酸稳定的口服大环内酯类抗菌药物，在结构上与红霉素有关。 了解更多
  17. Chloroquine Phosphate
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    Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine Phosphate是一种4-氨基喹啉抗疟和抗类风湿药，也可作为ATM活化剂。 了解更多
  18. MRT68921
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    MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 抑制剂
    MRT68921是一种有效的双重自噬激酶ULK1/2抑制剂，IC50分别为2.9 nM和1.1 nM。 了解更多
  19. SBI-0206965
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    SBI-0206965

    Catalog No. A15795
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    ULK1 抑制剂
    SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。 了解更多
  20. SBC-115076
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    SBC-115076

    Catalog No. A15769
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    PCSK9 拮抗剂
    SBC-115076是抗蛋白原转化酶枯草杆菌蛋白酶kexin 9型（抗PCSK9）化合物，用于治疗和/或预防心血管疾病。 了解更多
  21. Spautin-1
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    Spautin-1

    Catalog No. A12942
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    Autophagy 抑制剂
    Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。 了解更多
  22. Hydroxychloroquine Sulfate
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    Hydroxychloroquine Sulfate

    Catalog No. A14208
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    Hydroxychloroquine Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿性关节炎和其他自身免疫性，炎性和皮肤病性疾病。还可以作为自噬和通行费样受体（TLR）7/9的抑制剂。 了解更多
  23. Flubendazole (Flutelmium)
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    Flubendazole (Flutelmium)

    Catalog No. A11656
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    autophagy inducer
    Flubendazole (Flutelmium)是一种驱虫药，用于保护犬猫体内的寄生虫和蠕虫。 了解更多
  24. STF-62247
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    STF-62247

    Catalog No. A10866
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    Autophagy Inducer
    STF-62247是一种小分子激动剂，可诱导已经失去von Hippel-Lindau（VHL）肿瘤抑制活性（IC50 = 625 nM）的肾细胞癌（RCC）细胞致死，并自噬。 了解更多
  25. Resveratrol
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    Resveratrol

    Catalog No. A10785
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    Resveratrol具有广泛的靶标，包括环氧合酶（COX，IC50 = 1.1μM），脂氧合酶（LOX，IC50 = 2.7μM），激酶，sirtuins和其他蛋白质。它具有抗癌，抗炎，降低血糖和其他有益的心血管作用。 了解更多

25 个项目

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  1. Inhibitor (抑制剂) (13)
  2. Antagonist (拮抗剂) (1)
  3. Activator (激活剂) (4)
  4. Inducer (诱导剂) (2)
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  1. Autophagy (1)
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