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AV-412 (MP412)是一种EGFR抑制剂，对EGFR，EGFRL858R，EGFRT790M，EGFRL858R/T790M和ErbB2的IC50分别为0.75、0.5、0.79、2.3、19 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.72 mL | 98.62 mL | 197.23 mL |
| 0.5 mM | 3.94 mL | 19.72 mL | 39.45 mL |
| 1 mM | 1.97 mL | 9.86 mL | 19.72 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
*The above data is based on the productmolecular weight 507.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15460 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 507.02 |
| Formula | C27H28ClFN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 451492-95-8 |
| Synonyms | av 412, av-412, MP 412, MP-412 |
| SMILES | O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O |
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