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Avitinib (AC0010)是一种基于吡咯并嘧啶的不可逆EGFR抑制剂，对EGFR L858R/T790M双重突变具有突变选择性，IC50值为0.18 nM，效力比野生型EGFR（IC50值为7.68 nM）高近43倍。它具有可比的抗肿瘤活性和耐受的毒性。
| In vitro | DMSO | 90 mg/mL (184.6 mM) | |
| Water | Insoluble | ||
| Ethanol | 90 mg/mL (184.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.51 mL | 102.56 mL | 205.12 mL |
| 0.5 mM | 4.1 mL | 20.51 mL | 41.02 mL |
| 1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
*The above data is based on the productmolecular weight 487.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16826 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 487.53 |
| Formula | C26H26FN7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1557267-42-1 |
| Synonyms | AC-0010, AC 0010, Abivertinib |
| SMILES | C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O |
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