产品详情

生物活性

AVL-292是一种高选择性共价Btk抑制剂。

Targets

Target	Value
BTK	IC50: <0.5nM
YES	IC50: 723nM
c-Src	IC50: 1.729μM
BRK	IC50: 2.43μM
Lyn	IC50: 4.401μM
Fyn	IC50: 7.146μM
LCK	IC50: 9.079μM
CSK	IC50: >10μM
Hck	IC50: 14.46μM

溶解度 *

In vitro	DMSO	78 mg/mL (184.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.62 mL	118.08 mL	236.16 mL
0.5 mM	4.72 mL	23.62 mL	47.23 mL
1 mM	2.36 mL	11.81 mL	23.62 mL
5 mM	0.47 mL	2.36 mL	4.72 mL

*The above data is based on the productmolecular weight 423.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13202
作用机制	Inhibitor (抑制剂)
M. Wt	423.44
Formula	C22H22FN5O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1202757-89-8
Synonyms	AVL292, AVL 292, CC292, CC-292, CC 292
SMILES	COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F