产品详情

生物活性

AZ191是一种有效的选择性DYRK1B抑制剂，IC50为17 nM，选择性比DYRK1A和DYRK2高5到110倍。

靶点信息

Dyrk1B (Cell-free assay)	DYRK1A (Cell-free assay)	DYRK2 (Cell-free assay)
17 nM	88 nM	1890 nM

溶解度 *

In vitro	DMSO	81 mg/mL (188.58 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.28 mL	116.41 mL	232.82 mL
0.5 mM	4.66 mL	23.28 mL	46.56 mL
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 429.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14314
作用机制	Inhibitor (抑制剂)
M. Wt	429.52
Formula	C24H27N7O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1594092-37-1
Synonyms	AZ 191, AZ-191
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC