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AZ31是一种新的选择性ATM抑制剂，IC50<0.0012 uM，对密切相关的酶具有良好的选择性（对DNA-PK和PI3Kα的选择性大于500倍，对mTOR、PI3Kβ和PI3Kγ的选择性大于1000倍）。
| In vitro | DMSO | 46 mg/mL (109.39 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.78 mL | 118.91 mL | 237.81 mL |
| 0.5 mM | 4.76 mL | 23.78 mL | 47.56 mL |
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 420.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16813 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 420.5 |
| Formula | C24H28N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2088113-98-6 |
| Synonyms | AZ 31, AZ-31 |
| SMILES | NC(C1=C(N[C@H](C2CCOCC2)C)C3=CC(C4=CN=C(COC)C=C4)=CC=C3N=C1)=O |
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