微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。
靶点信息
| L858R/T790M EGFR (LoVo cells) | Exon 19 deletion EGFR (LoVo cells) | WT EGFR (LoVo cells) | ||
| 11.44 nM | 12.92 nM | 493.8 nM |
| In vitro (25°C) | DMSO | Warmed: 90 mg/mL (180.14 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 39 mg/mL (78.05 mM) | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 7.1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.02 mL | 100.08 mL | 200.16 mL |
| 0.5 mM | 4 mL | 20.02 mL | 40.03 mL |
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13681 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 499.61 |
| Formula | C28H33N7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1421373-65-0 |
| Synonyms | AZD 9291, AZD9291 |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC |
产品资料
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Gefitinib (Iressa)
Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。
Boceprevir (SCH-503034)
Boceprevir (SCH-503034)是一种蛋白酶抑制剂，可用于治疗C型肝炎基因型1。
BIBW2992 (Afatinib)
BIBW2992 (Afatinib)是酪氨酸激酶抑制剂（TKI），它不可逆地抑制人表皮生长因子受体2（Her2）和表皮生长因子…
Keywords:购买 AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) 供应商 | 订购 AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) 价格 | AZD-9291 (Osimertinib) 生产商 | 订单 AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) 代理商 | 购买 1421373-65-0| 1421373-65-0 供应商 | 订购 1421373-65-0 | 1421373-65-0 价格 | 1421373-65-0 生产商 | 订单 1421373-65-0 | 1421373-65-0 代理商|buy AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) Supplier | purchase AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) cost | AZD-9291 (Osimertinib) manufacturer | order AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) distributor | buy 1421373-65-0| 1421373-65-0 Supplier | purchase 1421373-65-0 | 1421373-65-0 cost | 1421373-65-0 manufacturer | order 1421373-65-0 | 1421373-65-0 distributor