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AZD3759是表皮生长因子受体（EGFR）的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。
靶点信息
| EGFR (L858R) | EGFR (exon 19Del) | EGFR (WT) | ||
| 0.2 nM | 0.2 nM | 0.3 nM |
| In vitro | DMSO | 80 mg/mL (173.94 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 18 mg/mL (39.13 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.74 mL | 108.72 mL | 217.44 mL |
| 0.5 mM | 4.35 mL | 21.74 mL | 43.49 mL |
| 1 mM | 2.17 mL | 10.87 mL | 21.74 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.35 mL |
*The above data is based on the productmolecular weight 459.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15551 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 459.9 |
| Formula | C22H23ClFN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1626387-80-1 |
| Synonyms | AZD 3759 |
| SMILES | CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C |
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