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AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
| In vitro (25°C) | DMSO | 79 mg/mL (183.11 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 79 mg/mL (183.11 mM) | ||
| In vivo | 5% dimethylacetamide and 20% hydroxypropyl-??-cyclodextrin in 0.3 M gluconic acid, pH 3, or 0.3 M gluconic acid, pH 3. | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.18 mL | 115.9 mL | 231.8 mL |
| 0.5 mM | 4.64 mL | 23.18 mL | 46.36 mL |
| 1 mM | 2.32 mL | 11.59 mL | 23.18 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
*The above data is based on the productmolecular weight 431.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21606 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 431.41 |
| Formula | C24H16F3N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1227163-84-9 |
| Synonyms | AZD 3839, AZD-3839 |
| SMILES | FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1 |
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